ReviewLife (Basel, Switzerland)2026
Circulating Lipids, Statins, and Metformin in Thoracic and Abdominal Aortic Aneurysm: A Systematic Review and Meta-Analysis.
Review in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thoracic and abdominal aortic aneurysms (TAA and AAA) progress silently, and no drug has been shown to slow their growth. Circulating lipids, statins, and metformin are candidate disease modifiers, but the evidence is heterogeneous and largely observational. We searched MEDLINE, Embase, and the Cochrane Library from inception to 24 March 2025, with an update of MEDLINE to 3 October 2026, for randomized and cohort studies of adults with established AAA or TAA. Aneurysm growth was standardized to mm/year and pooled with random-effects models when at least three comparable studies were available. Risk of bias and certainty of evidence were assessed with ROBINS-I and GRADE. Thirty-three studies were included, 32 observational and one randomized; fewer than 20% of participants were women. Circulating lipid fractions showed no consistent association with aneurysm growth. Statin use was associated with slower growth (mean difference -0.78 mm/year; 95% CI -1.13 to -0.43;
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