Fullerol Attenuates Diabetic Muscle Atrophy and Ferroptosis-Associated Injury: Intervention Timing Influences Myogenesis-Associated Responses In Vitro.

Zengguang Wang, Yuxin Zhang, Chen Xu, Dongyun Gu

Abstract read

In one paragraph

Article in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zengguang WangDepartment of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.

Yuxin ZhangDepartment of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.ORCID 0000-0001-7224-2533

Chen XuDepartment of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.

Dongyun GuDepartment of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.

Funding

China Postdoctoral Science Foundation 2025M781698National Key Research and Development Program of China 2022YFC2009502National Natural Science Foundation of China 82172402Postdoctoral Fellowship Program of CPSF GZB20260464Science and Technology Commission of Shanghai Municipality 25SF1908405

6 · The paper itself

Abstract

Glucolipotoxic stress contributes to diabetic muscle atrophy by disrupting myoblast homeostasis and myogenesis-associated responses. Fullerol is a water-soluble polyhydroxylated fullerene derivative with potent free-radical-scavenging activity. We investigated the protective effects of fullerol and compared concurrent and post-HGPA intervention schedules in C2C12 myoblasts. We evaluated C2C12 myoblasts exposed to high glucose plus palmitic acid (HGPA), RAW264.7 macrophages, macrophage-conditioned medium, and male C57BL/6J mice subjected to a high-fat diet (HFD) and streptozotocin (STZ). In the animal experiment, fullerol was administered locally during diabetic model development, whereas intervention timing was compared only in the C2C12 model. In myoblasts, HGPA induced Fe

Indexed as

diabetic muscle atrophyferroptosisfullerolglucolipotoxicityintervention timingmyogenesis-associated responses

Identifiers

PMID42942332

DOI10.3390/life16101746

PMCPMC13706367

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.