ArticleLife (Basel, Switzerland)2026
Severe Obstructive Sleep Apnea Is Associated with Cholesterol Target Non-Attainment in Patients Undergoing Cardiac Surgery: A Secondary Analysis of a Prospective Observational Cohort.
Article in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundObstructive sleep apnea (OSA) has been associated with adverse cardiometabolic profiles, but its relationship with cholesterol target attainment in patients receiving lipid-lowering therapy remains incompletely characterized. We investigated the association between severe OSA and non-attainment of predefined cholesterol thresholds in patients undergoing elective cardiac surgery.
methodsThis secondary analysis included 142 adults from a prospectively assembled observational cohort. Participants underwent in-hospital preoperative Type III cardiorespiratory polygraphy, fasting lipid assessment, and documentation of lipid-lowering therapy. Severe OSA was defined as an apnea-hypopnea index ≥30 events/h. The primary outcome was non-high-density lipoprotein cholesterol (non-HDL-C) ≥ 100 mg/dL. Multivariable models were adjusted for age, sex, body mass index, diabetes mellitus, high-intensity statin therapy, and non-statin lipid-lowering therapy.
resultsSevere OSA was associated with higher odds of non-HDL-C ≥ 100 mg/dL (adjusted odds ratio [OR] 3.49, 95% confidence interval [CI] 1.56-7.78;
conclusionsSevere OSA was associated with non-attainment of predefined cholesterol thresholds in this cardiac surgical cohort, with the strongest and most consistent association observed for non-HDL-C ≥ 100 mg/dL. These findings identify an association with categorical cholesterol target non-attainment but do not establish treatment failure, causality, or a generalized increase in cholesterol concentrations.
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