Evidence map›Paper›PMID 42942257›Full record

ArticleLife (Basel, Switzerland)2026

Vascular and Inflammatory Response Patterns Across Fixed-Sequence Handgrip Exercise Conditions in Hemodialysis Patients: An Exploratory Clinical Study with Complementary Experimental Findings.

Misa Miura, Mayura Shimura, Naoki Morito, Osamu Ito, Chie Saito, Satoshi Sakai, Kunihiro Yamagata, Masahiro Kohzuki, Yo Hirayama

Abstract read
In one paragraph

Article in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Misa MiuraFaculty of Health Sciences, Tsukuba University of Technology, Tsukuba 305-8521, Japan.ORCID 0000-0003-4773-1719
Mayura ShimuraFaculty of Health Sciences, Tsukuba University of Technology, Tsukuba 305-8521, Japan.ORCID 0009-0006-6835-4595
Naoki MoritoDepartment of Nephrology, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.ORCID 0000-0002-1967-8191
Osamu ItoDepartment of Rehabilitation Medicine, Tohoku Medical and Pharmaceutical University, Sendai 981-8558, Japan.ORCID 0000-0001-7583-5270
Chie SaitoDepartment of Nephrology, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.
Satoshi SakaiFaculty of Health Sciences, Tsukuba University of Technology, Tsukuba 305-8521, Japan.
Kunihiro YamagataDepartment of Nephrology, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.
Masahiro KohzukiYamagata Prefectural University of Health Sciences, Yamagata 990-2212, Japan.ORCID 0000-0002-7120-2641
Yo HirayamaHirayama Hospital, Chiba 262-0046, Japan.

Funding

Japan Society for the Promotion of Science JP21K11189, JP26K02753A
6 · The paper itself

Abstract

Patients undergoing hemodialysis (HD) frequently exhibit endothelial dysfunction and limited exercise capacity, but vascular and inflammatory responses to different handgrip exercise intensities remain unclear. Male Wistar rats with or without chronic kidney disease (CKD) underwent 4 weeks of forelimb exercise or no exercise (n = 5/group). In the clinical study, eight HD and eight non-HD participants completed fixed-sequence 2-week handgrip exercise conditions at 40%, 60%, and 80% of maximal voluntary contraction (MVC), separated by 2-week washouts. Peripheral arterial tonometry (PAT), inflammatory markers, and muscle strength were assessed. In rats, CKD was associated with lower body weight and spontaneous activity; exercise was not associated with significant differences in systolic blood pressure, serum creatinine trajectories, or inflammatory cytokines. Clinically, PAT showed a significant group-by-intensity interaction (

Indexed as

endothelial functionexercise intensityhandgrip exercisehemodialysisinflammation

Identifiers

PMID42942257
PMCPMC13705941

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.