Evidence map›Paper›PMID 42942185›Full record

ArticleLife (Basel, Switzerland)2026

Discordance Between Fasting Plasma Glucose- and HbA1c-Based Glycemic Classifications and Associated Metabolic and Hemodynamic Profiles in Thai Older Adults.

Nattaphol Prakobkaew, Orachorn Boonla, Surachat Buddhisa, Surada Satthakarn, Sudarat Boonpitak, Tichanon Promsrisuk, Piyapong Prasertsri

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In one paragraph

Article in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Nattaphol PrakobkaewFaculty of Allied Health Sciences, Burapha University, Chonburi 20131, Thailand.ORCID 0000-0002-8981-2480
Orachorn BoonlaFaculty of Allied Health Sciences, Burapha University, Chonburi 20131, Thailand.
Surachat BuddhisaFaculty of Allied Health Sciences, Burapha University, Chonburi 20131, Thailand.
Surada SatthakarnFaculty of Allied Health Sciences, Burapha University, Chonburi 20131, Thailand.
Sudarat BoonpitakFaculty of Allied Health Sciences, Burapha University, Chonburi 20131, Thailand.
Tichanon PromsrisukDivision of Physiology, School of Medical Sciences, University of Phayao, Phayao 56000, Thailand.ORCID 0000-0001-8523-2633
Piyapong PrasertsriFaculty of Allied Health Sciences, Burapha University, Chonburi 20131, Thailand.ORCID 0000-0003-2652-4622

Funding

Faculty of Allied Health Sciences, Burapha University AHS07/2566
6 · The paper itself

Abstract

backgroundFasting plasma glucose (FPG) and glycated hemoglobin (HbA1c) reflect different aspects of glycemic regulation and may yield discordant laboratory-defined classifications, particularly among older adults.

methodsThis cross-sectional analytical study included 203 community-dwelling Thai adults aged ≥60 years. Single FPG and HbA1c measurements were classified as normal-range, prediabetes-range, or diabetes-range values. Agreement was evaluated using exact agreement, Cohen's kappa (κ), linear-weighted κ, and symmetry tests. Four binary laboratory-defined phenotypes were compared using age- and sex-adjusted HC3 robust regression. The Benjamini-Hochberg procedure was applied separately across 13 omnibus tests and 39 phenotype-specific contrasts.

resultsExact three-category agreement was 70.9% (unweighted κ = 0.376; 95% CI, 0.247-0.498; weighted κ = 0.486; 95% CI, 0.355-0.601). Binary classifications were discordant in 25.6% of participants; HbA1c-only dysglycemia was numerically more frequent than FPG-only dysglycemia (15.8% vs. 9.9%), but directional asymmetry was not significant (

conclusionsFPG and HbA1c identified overlapping but non-equivalent laboratory-defined groups. Discordant single measurements warrant confirmation and evaluation of biological, analytical, and treatment-related influences; this study does not establish that routine dual testing improves diagnosis or outcomes.

Indexed as

cardiometabolic riskfasting plasma glucoseglycated hemoglobinglycemic discordanceolder adultspopulation screeningprediabetesThailand

Identifiers

PMID42942185
PMCPMC13705723

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.