Evidence map›Paper›PMID 42942157›Full record

ArticleInternational journal of molecular sciences2026

Evaluating dp-ucMGP, tMGP, and Fetuin-A as Markers of Combined Arterial Atherosclerotic Disease: A Cross-Sectional Study.

Teodora Bianca Tirla-Sirca, Mariana Eugenia Mureșan, Luciana Dobjanschi, Tamás Ilyés, Rodica Anamaria Negrean, Laura Grațiela Vicaș, Corina Cinezan, Elisabeta Cristina Crăciun Rusu, Camelia Mraz, Alexandra M Crăciun

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Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Teodora Bianca Tirla-SircaDoctoral School of Biomedical Sciences, University of Oradea, No. 1 University Street, 410087 Oradea, Romania.ORCID 0009-0007-3214-688X
Mariana Eugenia MureșanDoctoral School of Biomedical Sciences, University of Oradea, No. 1 University Street, 410087 Oradea, Romania.
Luciana DobjanschiDoctoral School of Biomedical Sciences, University of Oradea, No. 1 University Street, 410087 Oradea, Romania.ORCID 0000-0003-3788-1617
Tamás IlyésDepartment of Molecular Sciences, University of Medicine and Pharmacy "Iuliu Hațieganu", 400012 Cluj-Napoca, Romania.ORCID 0000-0001-5074-6212
Rodica Anamaria NegreanDepartment of Preclinical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 10 Piata 1 Decembrie Street, 410073 Oradea, Romania.ORCID 0000-0003-4865-2393
Laura Grațiela VicașDoctoral School of Biomedical Sciences, University of Oradea, No. 1 University Street, 410087 Oradea, Romania.ORCID 0000-0001-5328-333X
Corina CinezanDepartment of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania.ORCID 0009-0009-0855-938X
Elisabeta Cristina Crăciun RusuDoctoral School of Biomedical Sciences, University of Oradea, No. 1 University Street, 410087 Oradea, Romania.
Camelia MrazLaboratory Medicine, Bihor Public Health Directorate, Strada Libertății 34, 410040 Oradea, Romania.
Alexandra M CrăciunMedical Biochemistry, Department of Molecular Sciences, Faculty of Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania.ORCID 0000-0003-3703-1874

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vascular calcification and atherosclerotic arterial disease are complex processes involving multiple inhibitory and pro-calcific mechanisms. Matrix Gla protein (MGP) is an important inhibitor of vascular calcification, and its inactive dephosphorylated-uncarboxylated form (dp-ucMGP) has been proposed as a biomarker of cardiovascular risk. The present study aimed to evaluate the association of circulating dp-ucMGP, total MGP (tMGP), and Fetuin-A concentrations as markers for calcification associated with the presence of fibrocalcific plaques and/or arterial stenosis. A total of 160 patients were included in this observational study. Patients were classified according to the presence of fibrocalcific plaques and/or arterial stenosis. The study group included 136 patients, whereas 24 patients without fibrocalcific plaques or stenosis served as the control group. dp-ucMGP concentrations were significantly higher in the study group [1.29 vs. 1.07,

Indexed as

alpha-2-HS-GlycoproteinAtherosclerosisCalcium-Binding ProteinsExtracellular Matrix ProteinsAgedBiomarkersCross-Sectional StudiesFemaleHumansMaleMatrix Gla ProteinMiddle AgedVascular CalcificationAHSG protein, humanalpha-2-HS-GlycoproteinBiomarkersCalcium-Binding ProteinsExtracellular Matrix ProteinsMatrix Gla Proteinarterial stenosisatherosclerosiscardiovascular biomarkersdp-ucMGPFetuin-Afibrocalcific plaquematrix Gla proteinvascular calcification

Identifiers

PMID42942157
PMCPMC13704981

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.