ReviewInternational journal of molecular sciences2026
The Sedentary-Stress Paradox in Esports: Neuroendocrine, Metabolic, and Endothelial Pathways to Cardiovascular Risk.
Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
7 authors.
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Abstract
Esports and gaming resemble traditional sports and physical activity because both involve sustained cognitive and emotional stress; however, this stress occurs against a background of prolonged sedentary behavior. This narrative review examines the neuroendocrine, metabolic, and endothelial consequences of this "stress without movement" phenotype and its potential implications for long-term cardiovascular health. Activation of the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system disrupts sleep and circadian rhythms. Continuous neuroendocrine activation may impair muscle-adipose tissue crosstalk and nitric oxide-dependent endothelial function. Although direct longitudinal evidence linking gaming to cardiovascular disease is currently lacking, these convergent mechanisms identify prolonged sedentary gaming as a potential cardiovascular risk amplifier, particularly when combined with occupational sitting, sleep disruption, adiposity, and other cardiometabolic risk factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.