Evidence map›Paper›PMID 42941939›Full record

ReviewInternational journal of molecular sciences2026

From Chronic Infection to Microbial Imbalance: Rethinking Chronic Rhinosinusitis.

Jakub Piotr Łabaz, Martyna Guth, Jakub Szymon Kaleta, Julia Kaczmarek, Malwina Kinczel, Karolina Kornak, Marta Kaczor, Anna Leszczyszyn, Karolina Dorobisz, Katarzyna Pazdro-Zastawny

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jakub Piotr ŁabazFaculty of Medicine, Wroclaw Medical University, Ludwika Pasteura 1, 50-367 Wrocław, Poland.ORCID 0009-0007-4842-4258
Martyna GuthFaculty of Medicine, Wroclaw Medical University, Ludwika Pasteura 1, 50-367 Wrocław, Poland.
Jakub Szymon KaletaFaculty of Medicine, Wroclaw Medical University, Ludwika Pasteura 1, 50-367 Wrocław, Poland.
Julia KaczmarekFaculty of Medicine, Wroclaw Medical University, Ludwika Pasteura 1, 50-367 Wrocław, Poland.
Malwina KinczelFaculty of Medicine, Wroclaw Medical University, Ludwika Pasteura 1, 50-367 Wrocław, Poland.
Karolina KornakFaculty of Medicine, Wroclaw Medical University, Ludwika Pasteura 1, 50-367 Wrocław, Poland.
Marta KaczorFaculty of Medicine, Wroclaw Medical University, Ludwika Pasteura 1, 50-367 Wrocław, Poland.ORCID 0009-0008-0563-2628
Anna LeszczyszynMaxillofacial Surgery Department, 4th Military Clinical Hospital, Weigla 5, 50-981 Wroclaw, Poland.
Karolina DorobiszDepartment of Head and Neck Oncological Surgery, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland.ORCID 0000-0001-9369-8994
Katarzyna Pazdro-ZastawnyDepartment of Head and Neck Oncological Surgery, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic rhinosinusitis (CRS) has traditionally been viewed as a chronic inflammatory disease in which microbial factors are implicated. However, increasing evidence suggests that CRS may be better understood as a disruption of sinonasal microbial homeostasis rather than as a chronic infection caused by a single pathogen. This review summarizes current knowledge on healthy sinonasal microbiome composition and function as well as microbial alterations in CRS. Particular attention is given to dysbiosis involving potentially pathogenic microorganisms, including

Indexed as

DysbiosisMicrobiotaPersistent InfectionRhinosinusitisSinusitisAnimalsBiofilmsChronic DiseaseHomeostasisHumansPseudomonas aeruginosaStaphylococcus aureusbiofilmchronic rhinosinusitisdysbiosisepithelial barrierhost–microbiome interactionsmicrobial homeostasisPseudomonas aeruginosasinonasal microbiomeStaphylococcus aureus

Identifiers

PMID42941939
PMCPMC13705494

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.