Evidence map›Paper›PMID 42941901›Full record

ReviewInternational journal of molecular sciences2026

Metabolic Dysfunction and T-Cell Exhaustion in Colorectal Cancer: Mechanisms, Microenvironment Remodeling, and Therapeutic Opportunities.

Jieun Jeon, Hye Suk Baek, Kibeom Park, Mee-Na Park, Na Hyeon Heo, Sohyeon Cheon, Gahyeon Kim, Shin Kim

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jieun JeonDepartment of Immunology, School of Medicine, Keimyung University, Daegu 42601, Republic of Korea.ORCID 0009-0008-3211-536X
Hye Suk BaekDepartment of Immunology, School of Medicine, Keimyung University, Daegu 42601, Republic of Korea.ORCID 0009-0008-0767-0388
Kibeom ParkDepartment of Immunology, School of Medicine, Keimyung University, Daegu 42601, Republic of Korea.
Mee-Na ParkDepartment of Immunology, School of Medicine, Keimyung University, Daegu 42601, Republic of Korea.ORCID 0000-0002-8066-0134
Na Hyeon HeoDepartment of Immunology, School of Medicine, Keimyung University, Daegu 42601, Republic of Korea.
Sohyeon CheonSchool of Medicine, Keimyung University, Daegu 42601, Republic of Korea.ORCID 0009-0008-7297-2446
Gahyeon KimSchool of Medicine, Keimyung University, Daegu 42601, Republic of Korea.
Shin KimDepartment of Immunology, School of Medicine, Keimyung University, Daegu 42601, Republic of Korea.ORCID 0000-0002-1099-5027

Funding

National Research Foundation of Korea RS-2023-00249115National Research Foundation of Korea RS-2024-00439078National Research Foundation of Korea RS-2025-25430279
6 · The paper itself

Abstract

Colorectal cancer (CRC) remains a major cause of cancer-related morbidity and mortality worldwide. Metabolic disorders such as obesity, diabetes mellitus, dyslipidemia, and metabolic syndrome are associated with CRC risk. Metabolic abnormalities may contribute to colorectal tumorigenesis and reshape the tumor immune microenvironment, which in turn influence immune dysfunction and therapeutic resistance. Exhausted CD8

Indexed as

Colorectal NeoplasmsT-Cell ExhaustionTumor MicroenvironmentAnimalsHumansMetabolic Reprogrammingcolorectal cancerdiabetes mellitusimmune checkpoint blockadeimmunometabolismmetabolic dysfunctionmicrobiotaobesityT-cell exhaustiontherapeutic resistancetumor microenvironment

Identifiers

PMID42941901
PMCPMC13705190

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.