ArticleInternational journal of molecular sciences2026
6-Gingerol Potentiates β-Cell Insulin Secretion Without Acting as an L-Cell GLP-1 Secretagogue.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The incretin hormone glucagon-like peptide-1 (GLP-1) and its receptor (GLP-1R) are central regulators of glucose-stimulated insulin secretion and major targets in type 2 diabetes. 6-Gingerol, the principal bioactive constituent of ginger, has a reported insulinotropic action that depends on GLP-1 in vivo, but whether this reflects GLP-1 secretion from intestinal L-cells or signaling at the β-cell GLP-1R is unresolved. Using NCI-H716 and STC-1 L-cells and MIN6 β-cells, we examined whether 6-Gingerol acts as a GLP-1 secretagogue or at the β-cell. 6-Gingerol did not stimulate GLP-1 secretion. It had no effect in NCI-H716 cells and reduced secretion in STC-1 cells at concentrations that did not reduce viability. In MIN6 β-cells, 6-Gingerol potentiated insulin secretion in a bell-shaped manner. This effect was abolished by two mechanistically distinct GLP-1R antagonists and by protein kinase A inhibition and was accompanied by a GLP-1R-dependent rise in cAMP. MIN6 cells expressed
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