ArticleInternational journal of molecular sciences2026
Enzymatic Hydrolysate of Red Yeast Rice Accelerates Diabetic Wound Healing in Mice: Association with Modulation of Inflammatory, Matrix-Remodeling, and Angiogenesis-Related Markers.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Delayed healing of diabetic wounds arises from a self-sustaining pathological microenvironment featuring persistent inflammation, excessive matrix degradation, impaired angiogenesis, and insufficient collagen deposition, and current single-process interventions remain unsatisfactory. Red yeast rice, produced by fermentation of rice with Monascus spp., is a traditional fermented product with documented anti-inflammatory and antioxidant activities; however, its direct extract is dominated by macromolecular and bound-state constituents with low release efficiency and poor skin permeation, which restricts its topical application. In this study, an enzymatic hydrolysate of red yeast rice (RYR-EH) was prepared by composite enzymatic hydrolysis, and the compositional changes induced by hydrolysis were characterized by widely targeted UPLC-MS/MS metabolomics. A total of 810 metabolites were detected, among which 199 showed differential accumulation after hydrolysis (179 upregulated and 20 downregulated; FC ≥ 2 or ≤0.5, VIP ≥ 1, and
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