Evidence map›Paper›PMID 42939927›Full record

ReviewAntioxidants (Basel, Switzerland)2026

Sirtuin-1 in Hypertension: Linking Oxidative Stress and Mitochondrial Dysfunction to Vascular Aging and Therapeutic Potential.

Sandra Budziak, Monika Kloza, Przemysław Baranowski, Oskar Antoniak, Aniqa Saiyara, Marta Żarczyńska-Buchowiecka, Marcin Hellmann, Barbara Kutryb-Zając, Marta Baranowska-Kuczko

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sandra BudziakDepartment of Clinical Pharmacy, Medical University of Białystok, Mickiewicz Str. 2A, 15-089 Białystok, Poland.ORCID 0009-0001-1794-9947
Monika KlozaDepartment of Experimental Physiology and Pathophysiology, Medical University of Białystok, Mickiewicz Str. 2A, 15-089 Białystok, Poland.ORCID 0000-0001-7374-0999
Przemysław BaranowskiDepartment of Clinical Pharmacy, Medical University of Białystok, Mickiewicz Str. 2A, 15-089 Białystok, Poland.ORCID 0009-0005-8147-8579
Oskar AntoniakDepartment of Clinical Pharmacy, Medical University of Białystok, Mickiewicz Str. 2A, 15-089 Białystok, Poland.
Aniqa SaiyaraDepartment of Drug Addiction Pharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences, Smętna Str. 12, 31-343 Kraków, Poland.
Marta Żarczyńska-BuchowieckaDepartment of Cardiac Diagnostics, Medical University of Gdansk, Mariana Smoluchowskiego Str. 17, 80-214 Gdańsk, Poland.
Marcin HellmannDepartment of Cardiac Diagnostics, Medical University of Gdansk, Mariana Smoluchowskiego Str. 17, 80-214 Gdańsk, Poland.
Barbara Kutryb-ZającDepartment of Biochemistry, Medical University of Gdansk, Dębinki Str. 1, 80-211 Gdańsk, Poland.
Marta Baranowska-KuczkoDepartment of Clinical Pharmacy, Medical University of Białystok, Mickiewicz Str. 2A, 15-089 Białystok, Poland.ORCID 0000-0002-7238-2656

Funding

Medical University of Białystok B.SUB.24.344
6 · The paper itself

Abstract

Hypertension is a multifactorial cardiovascular disorder characterized by oxidative stress, endothelial dysfunction, chronic inflammation, mitochondrial impairment, and accelerated vascular aging, all of which contribute to hypertension-mediated target organ damage. Among the molecular pathways involved in these processes, sirtuin-1 (SIRT1), a nicotinamide adenine dinucleotide (NAD

Indexed as

hypertensionmitochondrial dysfunctionNAD+ metabolismoxidative stresssirtuin 1vascular agingvascular homeostasis

Identifiers

PMID42939927
PMCPMC13701266

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.