ArticleAntioxidants (Basel, Switzerland)2026
Circulating ELAFIN Is Associated with a Distinct Renal-Inflammatory Phenotype in Type 2 Diabetes Mellitus.
Beata Krasińska, Tomasz Urbanowicz, Minseung Kang, Siwon Baek, Ayoub Kourima, Priscilla Clarita, Mariusz Kowalewski, Giuseppe Maria Raffa, Calogera Pisano, Piotr Suwalski and 7 more
Abstract read
In one paragraphArticle in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
17 authors.
Beata KrasińskaDepartment of Hypertensiology, Angiology, and Internal Medicine, Poznan University of Medical Sciences, ½ Dluga Street, 61-848 Poznań, Poland.ORCID 0000-0002-3464-1645 Tomasz UrbanowiczCardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, ½ Długa, 61-848 Poznań, Poland.ORCID 0000-0001-8080-2764 Minseung KangCollege of Medicine, Korea University, 73 Goryeodae-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.ORCID 0009-0001-6144-5543 Siwon BaekCollege of Medicine, Inje University, 75 Bokji-ro, Busanjin-gu, Busan 47392, Republic of Korea.ORCID 0009-0004-9239-7822 Ayoub KourimaFaculty of Medicine and Pharmacy, Cadi Ayyad University, Sidi Abbad, B.P. 7010, Marrakech 40000, Morocco.ORCID 0009-0005-5347-5960 Priscilla ClaritaFaculty of Medicine, Universitas Airlangga, Jl. Mayjen Prof. Dr. Moestopo No. 47, Surabaya 60132, East Java, Indonesia.ORCID 0009-0008-1143-3713 Mariusz KowalewskiThoracic Research Center, Collegium Medicum, Nicolaus Copernicus University, 85-067 Bydgoszcz, Poland.ORCID 0000-0002-5478-3245 Giuseppe Maria RaffaDepartment of Precision Medicine in Medical Surgical and Critical Area (Me.Pre.C.C.), University of Palermo, 90134 Palermo, Italy.ORCID 0000-0001-7141-2561 Calogera PisanoDepartment of Precision Medicine in Medical Surgical and Critical Area (Me.Pre.C.C.), University of Palermo, 90134 Palermo, Italy.ORCID 0000-0002-6488-1965 Piotr SuwalskiDepartment of Cardiac Surgery, Center of Postgraduate Medical Education, Central Clinical Hospital of the Ministry of Interior, 02-507 Warszawa, Poland.
Ewelina WojtasińskaDepartment of Hematology, Transplantation and Cellular Therapy, Poznan University of Medical Sciences, 84 Szamarzewskiego Street, 60-569 Poznan, Poland.
Łukasz StryczyńskiDepartment of Hypertensiology, Angiology, and Internal Medicine, Poznan University of Medical Sciences, ½ Dluga Street, 61-848 Poznań, Poland.ORCID 0000-0002-8376-7180 Joanna KujawskaDepartment of Hematology, Transplantation and Cellular Therapy, Poznan University of Medical Sciences, 84 Szamarzewskiego Street, 60-569 Poznan, Poland.ORCID 0000-0003-3353-6947 Lidia GilDepartment of Hematology, Transplantation and Cellular Therapy, Poznan University of Medical Sciences, 84 Szamarzewskiego Street, 60-569 Poznan, Poland.
Zbigniew KrasińskiDepartment of Vascular, Endovascular Surgery, Angiology and Phlebology, Poznan University of Medical Science, ½ Dluga Street, 61-848 Poznan, Poland.ORCID 0000-0002-2798-1959 Joanna Rupa-MatysekDepartment of Hematology, Transplantation and Cellular Therapy, Poznan University of Medical Sciences, 84 Szamarzewskiego Street, 60-569 Poznan, Poland.ORCID 0000-0003-1585-6410 Andrzej TykarskiDepartment of Hypertensiology, Angiology, and Internal Medicine, Poznan University of Medical Sciences, ½ Dluga Street, 61-848 Poznań, Poland.
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
backgroundELAFIN (peptidase inhibitor 3, PI3) is an endogenous inhibitor of neutrophil elastase and proteinase 3, but its circulating profile in type 2 diabetes mellitus (T2DM) and cardiovascular disease remains poorly characterized. We investigated circulating ELAFIN in patients undergoing elective coronary angiography and explored its associations with metabolic, inflammatory, renal, cardiac, and angiographic phenotypes.
methodsForty-three consecutive clinically stable patients undergoing elective coronary angiography, including nine with T2DM, were prospectively enrolled. Plasma ELAFIN was quantified by ELISA. Associations with clinical and laboratory variables were assessed using non-parametric comparisons, correlation analyses, and parsimonious multivariable regression. Discrimination analyses were considered exploratory.
resultsMedian ELAFIN was 5.03-fold higher in patients with T2DM than in those without T2DM (31.2 [28.3-36.2] vs. 6.2 [5.5-7.0] ng/mL;
conclusionsCirculating ELAFIN was markedly elevated in T2DM and associated predominantly with renal and inflammatory characteristics rather than anatomical coronary disease or left ventricular dysfunction. Because oxidative stress and protease activity were not directly measured, their relationship with ELAFIN remains hypothesis-generating. These findings require validation in larger prospective cohorts.
Indexed as
biomarkerscoronary artery diseaseELAFINendothelial dysfunctionneutrophil elastaseoxidative stressprotease–antiprotease balanceredox biologytype 2 diabetes mellitusvascular inflammation
Identifiers
PMID42939889
PMCPMC13701232
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