ReviewCurrent issues in molecular biology2026
Laminin-Derived Peptides and Isoforms: A Multifaceted Review of Their Roles in Cancer, Neurodegeneration, Inflammation, Tissue Regeneration, and Exercise Physiology.
Review in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
Funding
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Abstract
backgroundLaminins are heterotrimeric basement membrane glycoproteins whose chain composition, molecular processing, receptor engagement, and cellular source determine their biological effects.
methodsWe conducted an integrative narrative search of PubMed and manually screened reference lists for studies of laminin isoforms, laminin-derived peptides, and polylaminin in cancer, neurological disorders, inflammation, tissue regeneration, wound healing, and exercise-related adaptation.
resultsThe evidence is heterogeneous and is predominantly mechanistic, in vitro, or preclinical. Laminin isoforms and derived peptides can produce opposing effects depending on the isoform or sequence, receptor, presentation format, tissue context, disease stage, and experimental model. Polylaminin is an experimental biomaterial with encouraging but preparation-dependent preclinical activity in selected neural repair models and in vitro stem cell culture.
conclusionsLaminin-based interventions should be developed in an indication-specific manner and require mechanistic validation, controlled delivery, dose-response characterization, safety assessment, reproducible manufacturing, and clinical validation before therapeutic translation.
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