Evidence map›Paper›PMID 42938426›Full record

ReviewGenes2026

An Evidence-Tiered Developmental Framework for Congenital Vertebral Malformations: Spatiotemporal Thresholds in Genotype-Phenotype Interpretation.

Xuhao Wang, Qi Zhang, Enze Ji, Yuchao Sui, Qingshuo Zhu, Kai Li, Xuhong Xue

Abstract readReview
In one paragraph

Review in Genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xuhao WangDepartment of Orthopedics, The Second Hospital of Shanxi Medical University, Taiyuan 030001, China.ORCID 0009-0003-4471-9105
Qi ZhangDepartment of Orthopedics, The Second Hospital of Shanxi Medical University, Taiyuan 030001, China.
Enze JiDepartment of Orthopedics, The Second Hospital of Shanxi Medical University, Taiyuan 030001, China.
Yuchao SuiDepartment of Orthopedics, The Second Hospital of Shanxi Medical University, Taiyuan 030001, China.
Qingshuo ZhuDepartment of Orthopedics, The Second Hospital of Shanxi Medical University, Taiyuan 030001, China.
Kai LiDepartment of Orthopedics, The Second Hospital of Shanxi Medical University, Taiyuan 030001, China.
Xuhong XueDepartment of Orthopedics, The Second Hospital of Shanxi Medical University, Taiyuan 030001, China.ORCID 0000-0003-2204-3039

Funding

National Natural Science Foundation of China 82272575
6 · The paper itself

Abstract

Congenital vertebral malformations (CVMs) encompass formation, segmentation and mixed defects, with or without scoliosis. This narrative review relates human genetic findings to paraxial mesoderm specification, somitogenesis, sclerotome differentiation and vertebral morphogenesis. An author-defined evidence hierarchy distinguishes established disease relationships, emerging susceptibility mechanisms and hypothesis-generating observations; it is not a formal ClinGen classification. Replicated

Indexed as

ScoliosisSpineAnimalsGenetic Association StudiesGenotypeHumansPhenotypeT-Box Domain ProteinsT-Box Domain ProteinsTBX6 protein, humancongenital vertebral malformationdevelopmental anomalydevelopmental thresholdgenotype–phenotype correlationsomitogenesisTBX6variant interpretation

Identifiers

PMID42938426
PMCPMC13704003

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.