ArticleComputational and structural biotechnology journal2026
SCOPE: A Spatial Co-registration and Omics Pipeline for Comparative Mass Spectrometry Imaging Data Analysis.
Article in Computational and structural biotechnology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Spatially resolved omics technologies have transformed our ability to map molecular organization within tissues. However, the absence of anatomically consistent spatial units across biological replicates fundamentally limits cross-sample comparison and rigorous population-level inference at high spatial fidelity. Current approaches rely either on segmentation-dependent region definitions, which risk obscuring fine-scale molecular heterogeneity, or on analyses confined to individual specimens without cross-replicate spatial correspondence. Here, we introduce SCOPE, a spatial co-registration and omics pipeline that integrates deformable image co-registration with a shared spatial reference, HexBin, to establish anatomically homologous spatial units across samples. By enabling segmentation-free comparison while preserving high spatial fidelity, SCOPE maintains intrinsic molecular heterogeneity and supports statistically robust cross-replicate comparison. Application of SCOPE to an
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