Evidence map›Paper›PMID 42934097›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2026

[PGAM5 deficiency attenuates atherosclerosis, enhances oxidized LDL uptake by liver sinusoidal endothelial cells and reshapes circulating lipidome in mice].

Huixin Tan, Junguo Jin, Manqi Yang, Jingli Wang, Fenghua Zhou, Ping Zeng, Xuegang Sun

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
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Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Huixin TanDepartment of Cardiology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou 510080, China.
Junguo JinDepartment of Cardiology, Peking University First Hospital, Beijing 100034, China.
Manqi YangDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
Jingli WangDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
Fenghua ZhouSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
Ping ZengDepartment of Cardiology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou 510080, China.
Xuegang SunSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.

Funding

National Natural Science Foundation of China 82074295 and 82374192
6 · The paper itself

Abstract

objectivesTo investigate the effects of mitochondrial phosphoglycerate mutase 5 (PGAM5) deficiency on endocytic function of liver sinusoidal endothelial cells (LSECs) and circulating lipid remodeling and their association with atherosclerosis (AS).

methodsAS was induced by tail vein injection of AAV-PCSK9 combined with Western diet (WD) feeding. Mice were divided into 5 groups: NC (negative control, normal chow feeding), ND (normal chow feeding after AAV-PCSK9 injection), WD (WD feeding after AAV-PCSK9 injection), ATOR (WD feeding plus atorvastatin calcium gavage after AAV-PCSK9 injection), and PGAM5 KO (PGAM5

resultsHepatic PGAM5 expression increased in AS. Compared with NC, WD mice showed increased aortic plaque burden, hepatic steatosis, and LDL-C abnormalities. Compared with WD, PGAM5 KO mice showed reduced aortic lipid deposition, enhanced plaque stability, decreased plasma low-density lipoprotein cholesterol (LDL-C) levels, and improved hepatic steatosis. Liver proteomics revealed differential protein enrichment in fatty acid metabolism and endocytosis pathways. Single-cell RNA-seq showed altered relative LSEC proportions following PGAM5 deficiency. Plasma metabolomics showed decreased L-palmitoylcarnitine (L-PC) and arachidonic acid (AA) levels in PGAM5

conclusionsPGAM5 deficiency is associated with enhanced endocytic function of LSECs and circulating lipid remodeling, which may contribute to ameliorated AS.

Indexed as

AtherosclerosisEndothelial CellsLipoproteins, LDLLiverMitochondrial ProteinsPhosphoglycerate MutaseAnimalsHumansLipid MetabolismLipidomicsMaleMiceMice, Inbred C57BLMice, KnockoutLipoproteins, LDLMitochondrial Proteinsoxidized low density lipoproteinPhosphoglycerate Mutaseatherosclerosisendocytosisliver sinusoidal endothelial cellsmitochondrial phosphoglycerate mutase 5

Identifiers

PMID42934097
PMCPMC13710997

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.