Efficient Synthesis of the Fungal Phytotoxin (±)-3-Deoxyradicinin.

Marilena Caporale, Giulia Marsico, Patrizia Scafato, Stefano Superchi

Abstract read

In one paragraph

Article in Toxins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Marilena CaporaleDepartment of Basic and Applied Sciences, University of Basilicata, Via dell'Ateneo Lucano 10, 85100 Potenza, Italy.

Giulia MarsicoDepartment of Basic and Applied Sciences, University of Basilicata, Via dell'Ateneo Lucano 10, 85100 Potenza, Italy.

Patrizia ScafatoDepartment of Basic and Applied Sciences, University of Basilicata, Via dell'Ateneo Lucano 10, 85100 Potenza, Italy.ORCID 0000-0002-6301-2856

Stefano SuperchiDepartment of Basic and Applied Sciences, University of Basilicata, Via dell'Ateneo Lucano 10, 85100 Potenza, Italy.ORCID 0000-0002-7265-1625

Funding

European Union CN00000022

6 · The paper itself

Abstract

An efficient synthesis of phytotoxin (±)-3-deoxyradicinin was developed from commercially available 4-hydroxy-6-methyl-2H-pyran-2-one. The propenyl side chain was introduced through regioselective bromination followed by Horner-Wadsworth-Emmons olefination, while the second pyranone ring was constructed via a Lewis acid-catalyzed reaction with crotonic acid. The synthetic route was designed according to the principles of operational simplicity, with the aim of minimizing the use of hazardous reagents and solvents, as well as demanding purification procedures and cryogenic conditions. These objectives were successfully achieved for most of the synthetic sequence, with the use of CCl

Indexed as

MycotoxinsPyronesMycotoxinsPyronesbioherbicidesfungal phytotoxinsgram-scale synthesisprocess optimizationtotal synthesisα-pyrones

Identifiers

PMID42931503

DOI10.3390/toxins18100412

PMCPMC13709763

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.