ArticleCells2026
Fibroblast-Derived PLA2G12A Amplifies Mast Cell Activation Through Extracellular Phospholipid Remodeling.
Yoshitaka Taketomi, Yoshimi Miki, Takayoshi Higashi, Yuki Nagasaki, Kuniyuki Kano, Makoto Arita, Junken Aoki, Makoto Murakami
Abstract read
In one paragraphArticle in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
8 authors.
Yoshitaka TaketomiLaboratory of Microenvironmental and Metabolic Health Science, Center for Disease Biology and Integrative Medicine (CDBIM), Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.ORCID 0000-0003-4094-9846 Yoshimi MikiLaboratory of Microenvironmental and Metabolic Health Science, Center for Disease Biology and Integrative Medicine (CDBIM), Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
Takayoshi HigashiLaboratory of Microenvironmental and Metabolic Health Science, Center for Disease Biology and Integrative Medicine (CDBIM), Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
Yuki NagasakiLaboratory of Microenvironmental and Metabolic Health Science, Center for Disease Biology and Integrative Medicine (CDBIM), Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.ORCID 0000-0002-4717-6877 Kuniyuki KanoDepartment of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Makoto AritaLaboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama City 230-0045, Kanagawa, Japan.
Junken AokiDepartment of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Makoto MurakamiLaboratory of Microenvironmental and Metabolic Health Science, Center for Disease Biology and Integrative Medicine (CDBIM), Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.ORCID 0000-0002-4565-6017 Funding
Japan Agency for Medical Research and Development JP20gm1210013Japan Agency for Medical Research and Development JP25gm2110005Japan Agency for Medical Research and Development JP25gm6910026Japan Society for the Promotion of Science JP18K06624Japan Society for the Promotion of Science JP20H05691Japan Society for the Promotion of Science JP25H01017Japan Society for the Promotion of Science JP25K02222Ministry of Education, Culture, Sports, Science and Technology JP25H01845
6 · The paper itselfAbstract
Extracellular vesicles (EVs) mediate intercellular communication, yet whether extracellular phospholipid metabolism on EV membranes regulates immune activation remains incompletely understood. Through comparative phenotypic analyses of multiple secreted phospholipase A
Indexed as
FibroblastsMast CellsPhospholipidsAnaphylaxisAnimalsExtracellular VesiclesHumansImmunoglobulin ELysophospholipidsMiceMice, Inbred C57BLMice, KnockoutImmunoglobulin ELysophospholipidsPhospholipidsanaphylaxisextracellular vesiclefibroblastlysophospholipidmast cellphospholipase A2
Identifiers
PMID42929821
PMCPMC13702701
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