Evidence map›Paper›PMID 42929812›Full record

ReviewCells2026

BAX, VDAC, Gasdermin, and Permeability Transition Pores in Inflammatory Mitochondrial DNA Release: Is This the "Hole" Story?

Naibo Zhang, Daniel D Freeman, Brian M Polster

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Naibo ZhangDepartment of Anesthesiology, Center for Shock, Trauma and Anesthesiology Research, and Program in Neuroscience, Baltimore, MD 21201, USA.
Daniel D FreemanDepartment of Anesthesiology, Center for Shock, Trauma and Anesthesiology Research, and Program in Neuroscience, Baltimore, MD 21201, USA.ORCID 0009-0004-8552-1645
Brian M PolsterDepartment of Anesthesiology, Center for Shock, Trauma and Anesthesiology Research, and Program in Neuroscience, Baltimore, MD 21201, USA.ORCID 0000-0003-2571-7510

Funding

Reprogramming proinflammatory microglia by restoring mitochondrial functionR01NS112212 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI POLSTER, BRIAN M · 2020 to 2024
$2.9M
Targeting mitochondrial Complex I in neonatal hypoxia-ischemiaR01NS122777 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI BRIAN M POLSTER, JAYLYN Waddell WADDELL · 2022 to 2026
$2.5M
Targeting TREM2 AD/ADRD risk and immunometabolism in human microgliaR21NS133527 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI POLSTER, BRIAN M · 2023 to 2023
$425k
NINDS NIH HHS R01 NS112212NINDS NIH HHS R01NS112212NINDS NIH HHS R01 NS122777NINDS NIH HHS R21 NS133527NINDS NIH HHS R21NS133527NINDS NIH HHS R21 NS133527 (B.M.P.).
6 · The paper itself

Abstract

Disease-modifying neuroprotective therapies for traumatic brain injury (TBI), stroke, and age-related neurodegenerative disorders have proven elusive. Interest in mitochondrial outer membrane permeabilization mechanisms as a drug target evolved from the 1990s discovery of BAX/BAK-mediated mitochondrial cytochrome

Indexed as

bcl-2-Associated X ProteinDNA, MitochondrialInflammationMitochondrial Permeability Transition PoreVoltage-Dependent Anion ChannelsAnimalsHumansMitochondriabcl-2-Associated X ProteinDNA, MitochondrialMitochondrial Permeability Transition PoreVoltage-Dependent Anion ChannelsapoptosiscGASinflammasomeMDVmitophagyMLKLmPTPmtDNANLRP3STING

Identifiers

PMID42929812
PMCPMC13702984

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.