SynthesisSystematic reviews2026
Chlorella for health: evidence from a GRADE-assessed systematic review and dose-response meta-analysis.
Synthesis in Systematic reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
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Abstract
backgroundChlorella species have attracted attention for their potential to improve cardiovascular and metabolic health; however, comprehensive evidence from controlled trials remains limited.
methodsA comprehensive search of PubMed, CENTRAL, Web of Science, Scopus, and EMBASE databases was conducted up to February 2025. Study quality and certainty of evidence were assessed using the Cochrane Risk of Bias and Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) tools, respectively.
resultsThirty-three studies were included. Chlorella supplementation led to significant reductions in body fat (Weighted Mean Difference [WMD] = -0.72%; 95% Confidence Interval [CI]: -1.09, -0.35; P < 0.001), body mass index (WMD = -0.29 kg/m
conclusionsChlorella supplementation demonstrates meaningful benefits for cardiometabolic health, with effects influenced by species, dosage, and participant characteristics. While this analysis has some limitations, further long-term studies are required to optimize its clinical application. Overall, Chlorella appears to be a promising supplement that may warrant inclusion in dietary interventions.
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