Evidence map›Paper›PMID 42924106›Full record

ReviewACS omega2026

The Role of Membranes in Tissue Regeneration Therapy: State of the Art and Future Perspectives.

Raphael Ferreira da Silva, Renata Ribeiro de Castro, Gabriela Warwar Teixeira, Paula de Souza Soares, Valéria Pereira de Sousa, Carlos Rangel Rodrigues, Flávia Almada do Carmo, Lucio Mendes Cabral

Abstract readReview
In one paragraph

Review in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Raphael Ferreira da SilvaDepartment of Drugs and Pharmaceutics, Faculty of Pharmacy, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-853, Brazil.
Renata Ribeiro de CastroInstituto de Tecnologia em Fármacos, Fundação Oswaldo Cruz, Rio de Janeiro 21041-250, Brazil.
Gabriela Warwar TeixeiraDepartment of Drugs and Pharmaceutics, Faculty of Pharmacy, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-853, Brazil.
Paula de Souza SoaresDepartment of Drugs and Pharmaceutics, Faculty of Pharmacy, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-853, Brazil.
Valéria Pereira de SousaDepartment of Drugs and Pharmaceutics, Faculty of Pharmacy, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-853, Brazil.
Carlos Rangel RodriguesDepartment of Drugs and Pharmaceutics, Faculty of Pharmacy, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-853, Brazil.
Flávia Almada do CarmoDepartment of Drugs and Pharmaceutics, Faculty of Pharmacy, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-853, Brazil.ORCID https://orcid.org/0000-0003-0474-9070
Lucio Mendes CabralDepartment of Drugs and Pharmaceutics, Faculty of Pharmacy, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-853, Brazil.ORCID https://orcid.org/0000-0002-4550-5729

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Membranes for tissue regeneration are an indispensable class of biomaterials in regenerative medicine, serving as selective barriers and matrices for the reconstruction of various tissues. Essential characteristics for the clinical success of a biomaterial include its biocompatibility, degradation kinetics, mechanical properties, and bioactivity, which are the focus of this review, with an emphasis on the importance of immunomodulation and the host response. The main clinical applications of this class of biomaterials are directed towards bone, cartilage, skin, and neural regeneration. In addition to evaluating the essential characteristics of these membranes, innovations such as smart, stimuli-responsive, and bioelectric membranes, as well as advances in 4D bioprinting, were also addressed. It is concluded that, despite established clinical success, the main challenges lie in overcoming material variability, vascularizing large-volume defects, and translating advanced technologies into clinical practice. Future perspectives point towards the development of personalized, smart, and bio-instructive membranes capable of actively orchestrating the regeneration process.

Identifiers

PMID42924106
PMCPMC13689299

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.