SynthesisRevista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia2026
HAIR-AN syndrome: a systematic review of clinical, metabolic, and hormonal features in women of reproductive age.
Synthesis in Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Objective: To synthesize the current evidence on the clinical, metabolic, and hormonal characteristics of HAIR-AN syndrome in women of reproductive age, and to evaluate current treatment options. Methods: A comprehensive literature search was conducted using PubMed, Embase, Scopus, and Web of Science databases up to June 2025. Eligible studies included observational and interventional designs reporting on women diagnosed with HAIR-AN syndrome. Data extraction focused on anthropometric, hormonal, and metabolic parameters. Risk of bias and methodological quality were assessed using the Newcastle-Ottawa Scale for observational studies and the Cochrane Risk of Bias tool for interventional studies. Results: From an initial pool of 226 records, five studies met inclusion criteria. Findings indicate that HAIR-AN syndrome predominantly affects obese women, with marked insulin resistance, hyperandrogenemia, and acanthosis nigricans severity correlating with metabolic dysfunction. Treatment strategies involving insulin-sensitizing agents, particularly incretin and metformin, demonstrated improvements in hormonal and metabolic profiles. Conclusion: HAIR-AN syndrome represents a unique and clinically relevant phenotype of severe IR with significant reproductive and dermatological manifestations. Early diagnosis and multidisciplinary management are essential to attenuate long-term metabolic complications.
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