Evidence map›Paper›PMID 42922890›Full record

ArticleMedComm2026

Applying Proteogenomics to Characterize Molecular Features Associated With a High-Risk HOXB13 Gene Variant in Prostate Cancer Tumors.

Kelsie Raspin, Zainab Noor, Adel T Aref, James R Marthick, Chol-Hee Jung, Shaun Donovan, Steve Williams, Peter G Hains, Phillip J Robinson, Rosemary L Balleine and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedComm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kelsie RaspinMenzies Institute for Medical Research University of Tasmania Hobart Tasmania Australia.
Zainab NoorProCan® Children's Medical Research Institute Faculty of Medicine and Health The University of Sydney Westmead New South Wales Australia.
Adel T ArefProCan® Children's Medical Research Institute Faculty of Medicine and Health The University of Sydney Westmead New South Wales Australia.
James R MarthickMenzies Institute for Medical Research University of Tasmania Hobart Tasmania Australia.
Chol-Hee JungMelbourne Bioinformatics The University of Melbourne Parkville Victoria Australia.
Shaun DonovanSonic Healthcare Hobart Tasmania Australia.
Steve WilliamsProCan® Children's Medical Research Institute Faculty of Medicine and Health The University of Sydney Westmead New South Wales Australia.
Peter G HainsProCan® Children's Medical Research Institute Faculty of Medicine and Health The University of Sydney Westmead New South Wales Australia.
Phillip J RobinsonProCan® Children's Medical Research Institute Faculty of Medicine and Health The University of Sydney Westmead New South Wales Australia.
Rosemary L BalleineProCan® Children's Medical Research Institute Faculty of Medicine and Health The University of Sydney Westmead New South Wales Australia.
Qing ZhongProCan® Children's Medical Research Institute Faculty of Medicine and Health The University of Sydney Westmead New South Wales Australia.
Roger R ReddelProCan® Children's Medical Research Institute Faculty of Medicine and Health The University of Sydney Westmead New South Wales Australia.
Liesel M FitzGeraldMenzies Institute for Medical Research University of Tasmania Hobart Tasmania Australia.
Joanne L DickinsonMenzies Institute for Medical Research University of Tasmania Hobart Tasmania Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rare HOXB13 G84E variant is one of few established high-risk prostate cancer (PrCa) variants, yet the underlying molecular mechanisms by which it drives tumor development remain unknown. Prostate tumors from six heterozygous G84E variant carriers and 18 non-carriers (wild-type) were examined using the Human AmpliSeq Transcriptome Gene Expression Panel, and proteomes were generated by mass spectrometry (SWATH). We identified a 799-gene expression profile and a 75-protein expression profile in G84E-positive tumors when compared with wild-type tumors. Cluster analysis revealed a top-ranked 23 protein profile, which mapped to lipogenesis pathways. Integration of transcriptome and proteome data revealed overlapping differential expression of three genes (

Indexed as

gene signatureHOXB13prostate cancerprostate tumorsproteogenomicrare variants

Identifiers

PMID42922890
PMCPMC13687195

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.