Evidence map›Paper›PMID 42922571›Full record

ArticlebioRxiv : the preprint server for biology2026

Biased signaling via NtsR1 restrains food intake and weight gain in obese mice.

Jariel Ramírez-Virella, Katherine Black, Netanya F Dennis, Raluca Bugescu, Katie Thompson, Steven H Olson, Lauren M Slosky, Zoe A McElligott, Gina M Leinninger

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jariel Ramírez-VirellaNeuroscience Program, Michigan State University, East Lansing, MI, USA.
Katherine BlackNeuroscience Program, Michigan State University, East Lansing, MI, USA.
Netanya F DennisDepartment of Physiology, Michigan State University, East Lansing, MI, USA.
Raluca BugescuDepartment of Physiology, Michigan State University, East Lansing, MI, USA.
Katie ThompsonNeuroscience Program, Michigan State University, East Lansing, MI, USA.
Steven H OlsonMedicinal Chemistry, Sanford Burnham Prebys, La Jolla, CA, USA.
Lauren M SloskyDepartment of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, USA.
Zoe A McElligottDepartment of Psychiatry, University of North Carolina Chapel Hill, NC, USA.
Gina M LeinningerNeuroscience Program, Michigan State University, East Lansing, MI, USA.ORCID 0000-0002-4823-4346

Funding

Role of Lateral Hypothalamic Neurotensin Neurons in Energy BalanceR01DK103808 · NIDDK · MICHIGAN STATE UNIVERSITY · PI Gina Marie Leinninger · 2014 to 2026
$4.8M
Integrative Pharmacological Sciences Training Program (IPSTP)T32GM142521 · NIGMS · MICHIGAN STATE UNIVERSITY · PI ANNE M. DORRANCE, Gina Marie Leinninger · 2021 to 2026
$2.4M
Neurotensin receptor 1 as a novel target for opioid use disorder and discovery of new small molecule probesR01DA061773 · NIDA · UNIVERSITY OF MINNESOTA · PI Steven H Olson, Lauren M Slosky · 2024 to 2026
$2.1M
Probing central amygdala neurotensin neurons in alcohol consumptionR01AA026363 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MCELLIGOTT, ZOE ANASTASIA · 2020 to 2024
$2.0M
Role of Central Neurotensin Signaling in the Ventral Tegmental Area for Ingestive Behavior and Body WeightF31DK134157 · NIDDK · MICHIGAN STATE UNIVERSITY · PI RAMIREZ-VIRELLA, JARIEL YAMIL · 2022 to 2024
$143k
NIAAA NIH HHS R01 AA026363NIDA NIH HHS R01 DA061773NIDDK NIH HHS F31 DK134157NIDDK NIH HHS R01 DK103808NIGMS NIH HHS T32 GM142521
6 · The paper itself

Abstract

Neurotensin receptor 1 (NTSR1) activation suppresses feeding and promotes weight loss but is limited by adverse effects associated with Gq signaling. SBI-553 is a β-arrestin-biased allosteric modulator of NTSR1 that avoids these effects. We evaluated the effects of SBI-553 (5 or 12 mg/kg, i.p.) on food intake and body weight in lean and diet-induced obese mice. Neither dose altered metabolic parameters, locomotor activity, or wheel running. SBI-553 did not affect ad libitum feeding in lean mice; however, both doses acutely reduced high-fat diet intake in obese mice. While 5 mg/kg had no effect on hunger-induced feeding, 12 mg/kg suppressed refeeding in both chow- and high-fat-fed mice of both sexes and reduced weight regain in obese mice. These findings identify SBI-553 as a potential strategy for reducing food intake and supporting weight loss.

Indexed as

brainfeedingNeurotensinobesitySBI-553

Identifiers

PMID42922571
PMCPMC13684580

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.