Evidence map›Paper›PMID 42922093›Full record

ArticleChemistry & biodiversity2026

Comparative Evaluation of Ethanolic Extracts Obtained From the Seeds of White and Black Açai Exhibit Antioxidant and Cytoprotective Activity In Vitro.

Luana França Calandrini de Azevedo, Estanislaw Tairowite Prestes Correa, Hemilly Casanova Gonçalves Soeiro, Oscar Vinícius Moraes Dos Santos, Gustavo Henrique da Silva Lopes, Karina Motta Melo, Vinicius Silva de Carvalho, Andryo Orfi de Almada Vilhena, Jorge das Dores Rissino, Karen Albuquerque Dias da Costa and 3 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Luana França Calandrini de Azevedo *Laboratório de Citogenética, Centro de Estudos Avançados da Biodiversidade, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.
Estanislaw Tairowite Prestes Correa *Laboratório de Citogenética, Centro de Estudos Avançados da Biodiversidade, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.
Hemilly Casanova Gonçalves SoeiroLaboratório de Citogenética, Centro de Estudos Avançados da Biodiversidade, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.
Oscar Vinícius Moraes Dos SantosLaboratório de Citogenética, Centro de Estudos Avançados da Biodiversidade, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.ORCID https://orcid.org/0000-0001-5156-6512
Gustavo Henrique da Silva LopesLaboratório de Citogenética, Centro de Estudos Avançados da Biodiversidade, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.
Karina Motta MeloLaboratório de Citogenética, Centro de Estudos Avançados da Biodiversidade, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.
Vinicius Silva de CarvalhoLaboratório de Citogenética, Centro de Estudos Avançados da Biodiversidade, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.
Andryo Orfi de Almada VilhenaLaboratório de Citogenética, Centro de Estudos Avançados da Biodiversidade, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.
Jorge das Dores RissinoLaboratório de Citogenética, Centro de Estudos Avançados da Biodiversidade, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.
Karen Albuquerque Dias da CostaO Laboratório de Investigação Sistemática em Biotecnologia e Biodiversidade Molecular, Instituto de Ciências Exatas e Naturais, Universidade Federal do Pará, Belém, Pará, Brazil.
Alberdan da Silva SantosO Laboratório de Investigação Sistemática em Biotecnologia e Biodiversidade Molecular, Instituto de Ciências Exatas e Naturais, Universidade Federal do Pará, Belém, Pará, Brazil.
Cleusa Yoshiko NagamachiLaboratório de Citogenética, Centro de Estudos Avançados da Biodiversidade, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.ORCID https://orcid.org/0000-0003-1516-2734
Julio Cesar PieczarkaLaboratório de Citogenética, Centro de Estudos Avançados da Biodiversidade, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.ORCID https://orcid.org/0000-0003-2951-8877

Funding

Coordination for the Improvement of Higher Education Personnel (CAPES) 047/2012National Bank for Economic and Social Development 2.318.697.0001National Bank for Economic and Social Development 307170/2021-7National Council for Scientific and Technological Development (CNPQ) 307154/2021-1National Council for Scientific and Technological Development (CNPQ) 307170/2021-7
6 · The paper itself

Abstract

The açai fruit (Euterpe oleracea) is valued for bioactive properties beyond nutrition, with its seed typically discarded as waste. This study evaluated ethanolic extracts from black (BA) and white (WA) açai seeds for antioxidant, cytotoxic, cytoprotective, and genotoxic activities in vitro. Using DPPH, MTT, and micronucleus assays on normal (MNP01) and gastric adenocarcinoma (ACP02) cell lines, both extracts showed antioxidant activity (BA ∼30% more effective than WA). Neither cytotoxic nor genotoxic effects were observed, but both exhibited cytoprotective properties in short-term assays. In clonogenic assays, BA (200 µg/mL) inhibited colony formation in both lines but did not interfere with cisplatin's efficacy. The findings suggest açai seed extracts offer transient cytoprotection, likely due to phenolic content and free radical scavenging, warranting further study for potential therapeutic applications.

Indexed as

AntioxidantsArecaceaeCytoprotectionEthanolPlant ExtractsSeedsBiphenyl CompoundsCell Line, TumorCell SurvivalDose-Response Relationship, DrugHumansPicratesAntioxidantsBiphenyl CompoundsEthanolPicratesPlant Extractsantioxidantcell linecytoprotectivenutrigenomicsseed

Identifiers

PMID42922093
PMCPMC13691405

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.