ReviewFrontiers in genetics2026
The "mobile bricks" of human evolution: how transposable elements shaped human phenotypes.
Review in Frontiers in genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Far from being "junk" and devoid of function, transposable elements have been identified as players in genomes evolution and regulation, and are also used as valuable genetic markers to study population differentiation. Here we present a detailed review on how transposons participated in human evolution: from adaptation to extreme environments and response to both internal and external stressors, to phenotypes directly emerging from transposon mobilization activities. We dedicate a section to brain plasticity and neuronal differentiation, highlighting the possible role of transposable elements in neuro-psychiatric disorders in the context of emerging hypotheses such as the
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