Evidence map›Paper›PMID 42920189›Full record

ArticleItalian journal of pediatrics2026

Can mesenchymal stem cell and retinoic acid therapies more effectively reduce lung damage due to bronchopulmonary dysplasia?

Senem Alkan Özdemir, Eda Açıkgöz, Aslı Çelik, Osman Yılmaz, Meral Sarper, Gurur Garip, Esra Özer, Gülperi Öktem

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Article in Italian journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Senem Alkan ÖzdemirNeonatologist, HSU Izmir Faculty of Medicine, Dr Behcet Uz Child Disease and Surgery Training and Research Hospital, Izmir, Türkiye. drsenemalkan@gmail.com.
Eda AçıkgözSchool of Medicine, Department of Histology, Van Yüzüncü Yıl University, Van, Türkiye.
Aslı ÇelikDepartment of Laboratory Animal Science, Dokuz Eylul University, Izmir, Türkiye.
Osman YılmazDepartment of Laboratory Animal Science, Dokuz Eylul University, Izmir, Türkiye.
Meral SarperDivision of Stem Cell, HSU Gülhane Faculty of Medicine, Department of Histology, Izmir, Türkiye.
Gurur GaripSchool of Medicine, Department of Histology, Izmir Tınaztepe University, Izmir, Türkiye.
Esra ÖzerDivision of Neonatology, School of Medicine, Department of Pediatrics, Izmir Tınaztepe University, Izmir, Türkiye.
Gülperi ÖktemSchool of Medicine, Department of Histology, Ege University, Izmir, Türkiye.

Funding

Ege Üniversitesi Ege ÜniversitesiSağlık Bilimleri Üniversitesi Sağlık Bilimleri Üniversitesi
6 · The paper itself

Abstract

aimThe purpose of the present study was to assess the efficacy of retinoic acid (RA) treatment combined with mesenchymal stem cells (MSCs) compared to MSCs alone in lung injury due to bronchopulmonary dysplasia.

methods29 Wistar baby rats on the postnatal third day were used. The experiment started on the postnatal 3rd day after the birth of the cubs. It was continued until the postnatal 14th day. Hyperoxia system was created with the help of Plexiglas chambers. Bone marrow-derived stem cells (1 × 10

resultsHyperoxia significantly impaired lung structure, as demonstrated by increased mean linear intercept (MLI), alveolar size, and vessel wall thickness, along with decreased alveolar tissue distribution compared to the control group (p < 0.0001). Treatment with mesenchymal stem cells (MSCs) significantly improved these parameters compared to the hyperoxic group (p < 0.0001). Notably, combined MSCs+retinoic acid (RA) therapy resulted in further improvement, with morphometric findings approaching those of the control group. In addition, α-smooth muscle actin (α-SMA) expression, which was significantly increased in the hyperoxic group (p < 0.0001), was reduced in both treatment groups, with the most pronounced decrease observed in the MSCs + RA group.

conclusionThe combined treatment significantly decreased fibrosis and inflammation in the BPD model, and the best reduction was achieved with the combination of the two therapies.

Indexed as

Bronchopulmonary DysplasiaMesenchymal Stem Cell TransplantationTretinoinAnimalsAnimals, NewbornDisease Models, AnimalImmunohistochemistryMaleRatsRats, WistarTretinoinBronchopulmonary dysplasiaLung injuryPretermRetinoic acidStem cell

Identifiers

PMID42920189

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.