Evidence map›Paper›PMID 42920060›Full record

ArticleNeuroscience bulletin2026

Distinct Contributions and Sensorimotor Encoding of PV and FoxP2 Neurons in the External Globus Pallidus during Perceptual Decision-making.

Xiaotian Pu, Jingyu Ren, Taorong Xie, Kexin Zou, Jingze Xu, Yaping Li, Dechen Liu, Haishan Yao

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In one paragraph

Article in Neuroscience bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaotian PuInstitute of Neuroscience, State Key Laboratory of Brain Cognition and Brain-inspired Intelligence Technology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China.
Jingyu RenInstitute of Neuroscience, State Key Laboratory of Brain Cognition and Brain-inspired Intelligence Technology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China.
Taorong XieInstitute of Neuroscience, State Key Laboratory of Brain Cognition and Brain-inspired Intelligence Technology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China.
Kexin ZouInstitute of Neuroscience, State Key Laboratory of Brain Cognition and Brain-inspired Intelligence Technology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China.
Jingze XuInstitute of Neuroscience, State Key Laboratory of Brain Cognition and Brain-inspired Intelligence Technology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China.
Yaping LiInstitute of Neuroscience, State Key Laboratory of Brain Cognition and Brain-inspired Intelligence Technology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China.
Dechen LiuInstitute of Neuroscience, State Key Laboratory of Brain Cognition and Brain-inspired Intelligence Technology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China. dcliu@ion.ac.cn.ORCID http://orcid.org/0000-0002-3907-1119
Haishan YaoInstitute of Neuroscience, State Key Laboratory of Brain Cognition and Brain-inspired Intelligence Technology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China. haishanyao@ion.ac.cn.ORCID http://orcid.org/0000-0003-4974-9197

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The external globus pallidus (GPe), the central nucleus of the basal ganglia, comprises diverse cell types, including parvalbumin (PV) and forkhead box protein P2 (FoxP2) neurons. Their roles in movement regulation and sensory processing are well established; however, their contribution to perceptual decision-making remains unclear. Using a Go/No-Go visual task in mice, we found that optogenetic activation of either population impaired performance, whereas PV inhibition, but not FoxP2 inhibition, disrupted behavioral accuracy. Electrophysiological recordings showed that PV and FoxP2 neurons differentially encoded visual stimuli, licking movements, and trial outcomes. FoxP2 inhibition produced minimal changes in the spontaneous firing of substantia nigra pars reticulata (SNr) neurons. PV inhibition altered spontaneous SNr firing and, together with PV activation, altered task-evoked SNr activity, reducing the preference for reward-predicting stimuli in one subpopulation and unrewarded outcomes in another. These findings reveal the distinct roles of GPe PV and FoxP2 neurons in shaping perceptual decisions and modulating basal ganglia output.

Indexed as

External globus pallidusFoxP2 neuronsParvalbumin neuronsSensorimotor processingSubstantia nigra pars reticulata

Identifiers

PMID42920060

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.