ArticleArchives of toxicology2026
Risk assessment of oral exposure to cyclic siloxanes - octamethylcyclotetrasiloxane (D4) as an example.
Article in Archives of toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
Funding
Abstract
Published data on in vivo toxicity of octamethylcyclotetrasiloxane (D4) on rat kidneys was re-evaluated. It turned out that a molecular and biochemical mode of action (MOA) of D4 induced effects on kidneys and its human relevance is missing, which remains a gap in current knowledge. Increased kidney weights (also in recovery groups) were considered as D4 specific adverse effects. In vitro, cytotoxicity was observed for D4 in human (HEK293, CaKi-1) and canine (MDCK) kidney cell lines, while no toxicity was observed in human hepatic cell line HepG2. Proteomic profiling at low toxic doses, using KEGG pathway analysis revealed that proteins in ribosomes, t-RNA biosynthesis and carbon metabolism were down-regulated in HEK293 cells. This indicates, that main cellular processes were disturbed. In HepG2 cells, DNA replication was affected, but no decrease in cell viability occurred. A BMDL
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