Additive hepatotoxicity of seneciphylline and lasiocarpine mixtures: multi-omics insights into P53 driven apoptosis and a Warburg-like metabolic reprogramming.

Lu Yu-Shun, Shi Wen-Biao, Qian Yong-Zhong, Mu Xi-Yan, Chen Lu

Abstract read

In one paragraph

Article in Archives of toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lu Yu-Shun *Key Laboratory of Agro-Product Quality and Safety, Institute of Quality Standards and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.

Shi Wen-Biao *Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, 100091, China.

Qian Yong-ZhongKey Laboratory of Agro-Product Quality and Safety, Institute of Quality Standards and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.

Mu Xi-YanKey Laboratory of Agro-Product Quality and Safety, Institute of Quality Standards and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing, 100081, China. muxiyan@caas.cn.

Chen LuKey Laboratory of Agro-Product Quality and Safety, Institute of Quality Standards and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing, 100081, China. chenlu@caas.cn.

Funding

National Natural Science Foundation of China 32202184

6 · The paper itself

Abstract

Pyrrolizidine alkaloids (PAs) are widespread food contaminants whose co-occurrence poses serious yet poorly understood cumulative health risks. Here, using primary mouse hepatocytes and C57BL/6J mice combined with concentration addition (CA) and combination index (CI) models, we demonstrate that co-exposure to the prevalent 1,2-unsaturated PAs seneciphylline (Sp) and lasiocarpine (La) produces strictly additive hepatotoxicity across a wide concentration range (CI ≈ 1.0; 1/8 EC

Indexed as

Additive hepatotoxicityCumulative risk assessmentMetabolic reprogrammingMitochondrial apoptosisP53 signalingPyrrolizidine alkaloids

Identifiers

PMID42919939

DOI10.1038/s41467-021-20993-z

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.