Evidence map›Paper›PMID 42919927›Full record

ArticleNature cardiovascular research2026

Cardiomyocyte-expressed TGFβ programs early heart maturation and adult myocyte identity.

Rachel A Minerath, Rajesh K Kasam, Casey O Swoboda, Vikram Prasad, Kelly M Grimes, N Scott Blair, Hadi Khalil, Christina M Alfieri, Logan Eads, Anthony J Saviola and 9 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature cardiovascular research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Rachel A MinerathDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Rajesh K KasamDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Casey O SwobodaDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Vikram PrasadDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Kelly M GrimesDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
N Scott BlairDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Hadi KhalilDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Christina M AlfieriDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Logan EadsDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Anthony J SaviolaDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado, Aurora, CO, USA.ORCID http://orcid.org/0000-0001-6890-512X
Mohamad AzharDepartment of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC, USA.ORCID http://orcid.org/0000-0001-9228-8096
Lianjie MiaoDepartment of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy, Houston, TX, USA.
Mingfu WuDepartment of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy, Houston, TX, USA.
Michelle TallquistJohn A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, HI, USA.ORCID http://orcid.org/0000-0002-1383-144X
Kirk C HansenDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado, Aurora, CO, USA.
Matthew T WeirauchDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Katherine E YutzeyDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Douglas P MillayDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID http://orcid.org/0000-0001-5188-0720
Jeffery D MolkentinDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA. jeff.molkentin@cchmc.org.ORCID http://orcid.org/0000-0002-3558-6529

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
Tissue Repository CoreP30AR070549 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI Leah Claire Kottyan · 2016 to 2026
$7.7M
Regulation of cardiac inflammation by fibroblastsR01HL144067 · NHLBI · UNIVERSITY OF HAWAII AT MANOA · PI TALLQUIST, MICHELLE D · 2018 to 2021
$2.3M
U.S. Department of Health & Human Services | NIH | Office of Extramural Research, National Institutes of Health (OER) 1R01HL160765)U.S. Department of Health & Human Services | NIH | Office of Extramural Research, National Institutes of Health (OER) P30AR070549U.S. Department of Health & Human Services | NIH | Office of Extramural Research, National Institutes of Health (OER) P30CA046934U.S. Department of Health & Human Services | NIH | Office of Extramural Research, National Institutes of Health (OER) R01HL144067
6 · The paper itself

Abstract

Transforming growth factor β (TGFβ) is a secreted factor sequestered in the extracellular matrix (ECM), but its role in developing mouse heart maturation is unknown. Here we show that cardiomyocyte-specific deletion of Tgfb1, Tgfb2 and Tgfb3 genes (TGFβ ligands) in the developing heart results in cardiac dysfunction by 6 weeks of age, altered fibroblast activity, abnormal ECM properties and endothelial and immune changes. Gene profiling reveals defective cardiomyocyte/fibroblast maturation with cardiomyocyte ectopic skeletal muscle gene expression beginning at embryonic day 17.5 (E17.5). Cardiomyocyte deletion of Tgfbr1/Tgfbr2 or Smad2/Smad3 does not phenocopy Tgfb1/2/3 deletion, suggesting that cardiomyocyte TGFβ acts through non-myocytes to regulate heart maturation. Similarly, Col1a2

Identifiers

PMID42919927

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.