ArticleNature plants2026
Rewriting wheat karyotypes through centromere-targeted chromosome engineering.
Ximeng Zhou, Yiqian Chen, Chenyang Li, Wan Teng, Yingjie Cui, Xuelian Tan, Meijia Hu, Yue Zhou, Xiaoming Xie, Weilong Guo and 6 more
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In one paragraphArticle in Nature plants, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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16 authors.
Ximeng Zhou *State Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping/Frontiers Science Center for Molecular Design Breeding/Key Laboratory of Crop Heterosis and Utilization (MOE)/College of Agronomy and Biotechnology, China Agricultural University, Beijing, China.
Yiqian Chen *National Key Laboratory of Crop Genetic Improvement, Hubei Hongshan Laboratory, College of Bio-X, Huazhong Agricultural University, Wuhan, China.
Chenyang Li *State Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping/Frontiers Science Center for Molecular Design Breeding/Key Laboratory of Crop Heterosis and Utilization (MOE)/College of Agronomy and Biotechnology, China Agricultural University, Beijing, China.
Yingjie CuiState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping/Frontiers Science Center for Molecular Design Breeding/Key Laboratory of Crop Heterosis and Utilization (MOE)/College of Agronomy and Biotechnology, China Agricultural University, Beijing, China.
Xuelian TanNational Key Laboratory of Crop Genetic Improvement, Hubei Hongshan Laboratory, College of Bio-X, Huazhong Agricultural University, Wuhan, China.
Meijia HuNational Key Laboratory of Crop Genetic Improvement, Hubei Hongshan Laboratory, College of Bio-X, Huazhong Agricultural University, Wuhan, China.
Yue ZhouLaboratory of Advanced Breeding Technologies, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
Xiaoming XieState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping/Frontiers Science Center for Molecular Design Breeding/Key Laboratory of Crop Heterosis and Utilization (MOE)/College of Agronomy and Biotechnology, China Agricultural University, Beijing, China.ORCID http://orcid.org/0000-0002-7925-4964 Weilong GuoState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping/Frontiers Science Center for Molecular Design Breeding/Key Laboratory of Crop Heterosis and Utilization (MOE)/College of Agronomy and Biotechnology, China Agricultural University, Beijing, China.ORCID http://orcid.org/0000-0001-5199-1359 Qixin SunState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping/Frontiers Science Center for Molecular Design Breeding/Key Laboratory of Crop Heterosis and Utilization (MOE)/College of Agronomy and Biotechnology, China Agricultural University, Beijing, China.ORCID http://orcid.org/0000-0002-3819-6892 Zhongfu NiState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping/Frontiers Science Center for Molecular Design Breeding/Key Laboratory of Crop Heterosis and Utilization (MOE)/College of Agronomy and Biotechnology, China Agricultural University, Beijing, China. nizf@cau.edu.cn.ORCID http://orcid.org/0000-0003-4524-7720 Yanpeng WangLaboratory of Advanced Breeding Technologies, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China. yanpengwang@genetics.ac.cn.ORCID http://orcid.org/0000-0003-1577-6883 Handong SuNational Key Laboratory of Crop Genetic Improvement, Hubei Hongshan Laboratory, College of Bio-X, Huazhong Agricultural University, Wuhan, China. shandong@mail.hzau.edu.cn.ORCID http://orcid.org/0000-0001-8621-2941 Yuan ZongState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping/Frontiers Science Center for Molecular Design Breeding/Key Laboratory of Crop Heterosis and Utilization (MOE)/College of Agronomy and Biotechnology, China Agricultural University, Beijing, China. zongyuan@cau.edu.cn.ORCID http://orcid.org/0000-0003-0576-6614 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Engineering karyotypes could expand the genetic and breeding potential of crops, but restructuring gigabase-scale polyploid genomes remains challenging. Here we develop centromere editing-mediated chromosomal variation, a strategy using CRISPR-Cas9 to target abundant centromeric retrotransposons in hexaploid wheat. Centromere editing-mediated chromosomal variation efficiently induces simultaneous chromosome cleavage across the genome, generating diverse karyotypic variants and reconfiguring up to 11 chromosomes in one generation. Notably, it produces widespread reciprocal translocations, with one line carrying six events involving seven chromosomes. Newly formed translocation chromosomes undergo centromere remodelling, enabling their relatively stable maintenance and heritable transmission. Moreover, balanced translocations impose minimal transcriptional perturbation and maintaining normal growth. These results establish centromeres as effective sites for chromosome engineering breeding and provide a scalable framework for karyotype redesign in polyploid crops.
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