Evidence map›Paper›PMID 42919862›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2026

Respiratory support duration and the association between patent ductus arteriosus exposure and bronchopulmonary dysplasia.

Emel Okulu, Omer Erdeve, Zehra Arslan, Nihal Demirel, Abdullah Barış Akcan, Funda Tuzun Erdogan, Ali Bulbul, Hasan Sinan Uslu, Mehmet Yekta Oncel, Hilal Ozkan and 3 more

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Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Emel OkuluDivision of Neonatology, Department of Pediatrics, Ankara University School of Medicine, Ankara, Türkiye. emelokulu@gmail.com.ORCID http://orcid.org/0000-0002-1101-3355
Omer ErdeveDivision of Neonatology, Department of Pediatrics, Ankara University School of Medicine, Ankara, Türkiye.
Zehra ArslanDepartment of Neonatology, University of Health Sciences, Ankara Etlik City Hospital, Ankara, Türkiye.
Nihal DemirelDivision of Neonatology, Department of Pediatrics, Yıldırım Beyazıt University School of Medicine, Ankara, Türkiye.
Abdullah Barış AkcanDivision of Neonatology, Department of Pediatrics, Adnan Menderes University School of Medicine, Aydın, Türkiye.
Funda Tuzun ErdoganDivision of Neonatology, Department of Pediatrics, Dokuz Eylül University School of Medicine, Izmir, Türkiye.
Ali BulbulDepartment of Neonatology, University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Türkiye.ORCID http://orcid.org/0000-0002-3510-3056
Hasan Sinan UsluDepartment of Neonatology, University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Türkiye.
Mehmet Yekta OncelDivision of Neonatology, Department of Pediatrics, Izmir Bakircay University School of Medicine, Izmir, Türkiye.
Hilal OzkanDivision of Neonatology, Department of Pediatrics, Uludag University School of Medicine, Bursa, Türkiye.
Nilgun KoksalDivision of Neonatology, Department of Pediatrics, Uludag University School of Medicine, Bursa, Türkiye.
Esin KocDivision of Neonatology, Department of Pediatrics, Gazi University School of Medicine, Ankara, Türkiye.
Turkish Neonatal Society INTERPDA Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine whether the association between prolonged patent ductus arteriosus (PDA) exposure and bronchopulmonary dysplasia (BPD) differs according to the duration of invasive respiratory support in very preterm infants. STUDY

designThis secondary analysis of the multicenter, prospective INTERPDA cohort included infants born at <29 weeks' gestation with moderate-to-large PDA requiring respiratory support. Infants were stratified according to PDA exposure duration ( < 14 and ≥14 days) and cumulative invasive respiratory support duration ( < 10 and ≥10 days).

resultsAmong 363 infants, prolonged PDA exposure was associated with higher rates of moderate/severe BPD, BPD or death, and mortality only in infants requiring ≥10 days of respiratory support. In adjusted analyses, prolonged PDA exposure remained independently associated with these adverse outcomes.

conclusionProlonged PDA exposure was associated with adverse pulmonary outcomes primarily in infants with prolonged respiratory dependence, supporting an individualized, physiology-based approach to PDA management in very preterm infants.

Identifiers

PMID42919862

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.