Evidence map›Paper›PMID 42919835›Full record

ArticleMolecular psychiatry2026

The non-inflammatory effect of neuronal NLRP3 on spatial memory after traumatic brain injury.

Si-Wei Tan, Qing Xie, Jing Zhang, Ping Li, Ya-Lei Ning, Nan Yang, Bo Wang, Yan Peng, Xing Chen, Ruo-Bing Gao and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Si-Wei Tan *Department of Army Occupational Disease, State Key Laboratory of Trauma and Chemical Poisoning, Research Institute of Surgery and Daping Hospital, Army Medical University, Chongqing, 400042, China.
Qing Xie *Department of Army Occupational Disease, State Key Laboratory of Trauma and Chemical Poisoning, Research Institute of Surgery and Daping Hospital, Army Medical University, Chongqing, 400042, China.
Jing ZhangDepartment of Army Occupational Disease, State Key Laboratory of Trauma and Chemical Poisoning, Research Institute of Surgery and Daping Hospital, Army Medical University, Chongqing, 400042, China.
Ping LiDepartment of Army Occupational Disease, State Key Laboratory of Trauma and Chemical Poisoning, Research Institute of Surgery and Daping Hospital, Army Medical University, Chongqing, 400042, China.ORCID http://orcid.org/0000-0002-4926-3835
Ya-Lei NingDepartment of Army Occupational Disease, State Key Laboratory of Trauma and Chemical Poisoning, Research Institute of Surgery and Daping Hospital, Army Medical University, Chongqing, 400042, China.
Nan YangDepartment of Army Occupational Disease, State Key Laboratory of Trauma and Chemical Poisoning, Research Institute of Surgery and Daping Hospital, Army Medical University, Chongqing, 400042, China.
Bo WangDepartment of Army Occupational Disease, State Key Laboratory of Trauma and Chemical Poisoning, Research Institute of Surgery and Daping Hospital, Army Medical University, Chongqing, 400042, China.
Yan PengDepartment of Army Occupational Disease, State Key Laboratory of Trauma and Chemical Poisoning, Research Institute of Surgery and Daping Hospital, Army Medical University, Chongqing, 400042, China.
Xing ChenDepartment of Army Occupational Disease, State Key Laboratory of Trauma and Chemical Poisoning, Research Institute of Surgery and Daping Hospital, Army Medical University, Chongqing, 400042, China.
Ruo-Bing GaoDepartment of Army Occupational Disease, State Key Laboratory of Trauma and Chemical Poisoning, Research Institute of Surgery and Daping Hospital, Army Medical University, Chongqing, 400042, China.
Chang-Hong LiDepartment of Army Occupational Disease, State Key Laboratory of Trauma and Chemical Poisoning, Research Institute of Surgery and Daping Hospital, Army Medical University, Chongqing, 400042, China.
Hao DuDepartment of Army Occupational Disease, State Key Laboratory of Trauma and Chemical Poisoning, Research Institute of Surgery and Daping Hospital, Army Medical University, Chongqing, 400042, China.
Yuan-Guo ZhouDepartment of Army Occupational Disease, State Key Laboratory of Trauma and Chemical Poisoning, Research Institute of Surgery and Daping Hospital, Army Medical University, Chongqing, 400042, China. ygzhou@tmmu.edu.cn.
Yan ZhaoDepartment of Army Occupational Disease, State Key Laboratory of Trauma and Chemical Poisoning, Research Institute of Surgery and Daping Hospital, Army Medical University, Chongqing, 400042, China. yan.zhao@tmmu.edu.cn.ORCID http://orcid.org/0009-0004-9203-4749

Funding

National Natural Science Foundation of China (National Science Foundation of China) 31771118National Natural Science Foundation of China (National Science Foundation of China) 81771176
6 · The paper itself

Abstract

The NLRP3 inflammasome has emerged as a critical regulator in neuroinflammatory responses to various brain insults from traumatic, ischemic and neurodegenerative conditions, an effect almost exclusively attributed to microglial NLRP3. Here, we demonstrated that in the absence of changes in inflammatory factors IL-18, IL-1β and TNF-α, neuronal Nlrp3 knockout in hippocampus (nNlrp3

Identifiers

PMID42919835

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.