Evidence map›Paper›PMID 42919422›Full record

ArticleBMC pharmacology & toxicology2026

The pan-African natural products library compounds oleanolic acid, poinsettifolin B, and rhuschalcone III disrupt SARS-CoV-2 spike-host ACE2 interactions and SARS-CoV-2 replication.

Mathieu J M Tjegbe, Pascal Amoa Onguéné, Boris D Bekono, Jude Y Betow, Conrad V Simoben, Joel Cassel, Joseph M Salvino, Luis J Montaner, Kerstin Andrae-Marobela, Fidele Ntie-Kang and 1 more

Abstract read
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In one paragraph

Article in BMC pharmacology & toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mathieu J M TjegbeCenter for Drug Discovery, Faculty of Science, University of Buea, P. O. Box 63, Buea, Cameroon.ORCID http://orcid.org/0009-0006-0615-0335
Pascal Amoa OnguénéUniversity Institute of Wood Technology, University of Yaoundé 1, Mbalmayo Campus, Mbalmayo, Cameroon.ORCID http://orcid.org/0000-0003-2919-6089
Boris D BekonoDepartment of Physics, Ecole Normale Supérieure, University of Yaoundé 1, P. O. Box 47, Yaoundé, Cameroon.ORCID http://orcid.org/0000-0003-1077-4176
Jude Y BetowCenter for Drug Discovery, Faculty of Science, University of Buea, P. O. Box 63, Buea, Cameroon.ORCID http://orcid.org/0009-0004-5503-8281
Conrad V SimobenCenter for Drug Discovery, Faculty of Science, University of Buea, P. O. Box 63, Buea, Cameroon.ORCID http://orcid.org/0000-0002-5958-6961
Joel CasselThe Wistar Institute, Philadelphia, PA, 19104, USA.ORCID http://orcid.org/0000-0001-8465-8739
Joseph M SalvinoThe Wistar Institute, Philadelphia, PA, 19104, USA.ORCID http://orcid.org/0000-0002-2184-5980
Luis J MontanerThe Wistar Institute, Philadelphia, PA, 19104, USA.ORCID http://orcid.org/0000-0001-5799-6759
Kerstin Andrae-MarobelaDepartment of Biological Sciences, University of Botswana, Gaborone, Botswana.ORCID http://orcid.org/0000-0002-2103-6374
Fidele Ntie-KangCenter for Drug Discovery, Faculty of Science, University of Buea, P. O. Box 63, Buea, Cameroon. fidele.ntie-kang@ubuea.cm.ORCID http://orcid.org/0000-0003-0795-394X
Ian TietjenThe Wistar Institute, Philadelphia, PA, 19104, USA. ian.tietjen@delval.edu.ORCID http://orcid.org/0000-0002-8991-6490

Funding

Alexander von Humboldt Foundation 1156361 CMR-IPBill and Melinda Gates Foundation INV-036848Canadian Institutes for Health Research PJT-153057LifeArc 10646
6 · The paper itself

Abstract

Natural product (NP)-based chemical libraries are a rich source of antiviral compounds that can serve as the basis for new therapeutic leads to treat viral diseases, particularly for individuals lacking sustained access to existing vaccines and therapeutics. To identify new NP-based candidate inhibitors of SARS-CoV-2 cellular entry and viral replication, we screened the pan-African Natural Products Library (p-ANAPL), a collection of physical pure compounds obtained from African medicinal plants, for NPs that can disrupt the in vitro interaction of the SARS-CoV-2 Spike receptor-binding domain (RBD) with its host ACE2 entry receptor. This screen identified three compounds - oleanolic acid, poinsettifolin B, and rhuschalcone III - which disrupt RBD/ACE2 interactions with half-maximal inhibitory concentrations (IC

Indexed as

Angiotensin-Converting Enzyme 2Antiviral AgentsBiological ProductsChalconesOleanolic AcidSARS-CoV-2Spike Glycoprotein, CoronavirusVirus ReplicationAnimalsChlorocebus aethiopsHumansVero CellsVirus InternalizationACE2 protein, humanAngiotensin-Converting Enzyme 2Antiviral AgentsBiological ProductsChalconesOleanolic AcidSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2AntiviralsNatural productsp-ANAPLSARS-CoV-2Viral entry

Identifiers

PMID42919422

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.