ArticleBMC pediatrics2026
Minimally invasive management of pediatric hereditary spherocytosis: severity-stratified biliary risk and indications for simultaneous cholecystectomy and biliary intervention at laparoscopic splenectomy - a single-center retrospective study.
Article in BMC pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundHereditary spherocytosis (HS) is an inherited hemolytic anemia in which splenectomy may be indicated in moderate to severe disease. Chronic hemolysis increases the risk of cholelithiasis and biliary complications, but optimal timing of cholecystectomy remains uncertain.
methodsA retrospective single-center analysis of pediatric patients with moderate to severe HS who underwent laparoscopic splenectomy between January 2017 and January 2024. Evaluated variables included disease severity, demographics, cholelithiasis, biliary manifestations, requirement for endoscopic retrograde cholangiopancreatography (ERCP), operative time, postoperative complications, and length of hospital stay.
resultsThirteen patients were included (5 male, 8 female; mean age 11.9 ± 4.3 years): 6 with moderate HS and 7 with severe HS. Cholelithiasis was present in 9 patients (69.2%). Major biliary complications (biliary pancreatitis or obstructive jaundice) occurred in 4/7 patients with severe HS (57.1%) compared with 1/6 patients with moderate HS (16.7%); ERCP was required in the same proportions. Mean operative time was 124.7 ± 44.7 min and mean hospital stay was 6.1 ± 1.9 days. No major postoperative surgical complications occurred; one patient developed pleural effusion (Clavien-Dindo grade I). Hemoglobin, reticulocyte count, and bilirubin levels improved after surgery and remained improved during follow-up.
conclusionsLaparoscopic splenectomy was safe and effective in this small cohort of children with hereditary spherocytosis. These preliminary findings suggest that children with severe HS and cholelithiasis may represent a subgroup in whom the potential role of concomitant or early cholecystectomy warrants prospective evaluation. Because of the small sample size, retrospective design and absence of a direct comparison between prophylactic and delayed cholecystectomy strategies, these findings should not be interpreted as a clinical recommendation. The data are insufficient to support a subgroup-specific conclusion for children with moderate HS.
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