ArticleBMC infectious diseases2026
Clinical utility of the inflammatory burden index in differentiating neonatal pneumonia from pneumonia complicated by sepsis.
Article in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectiveDifferentiating sepsis from uncomplicated pneumonia in neonates remains clinically challenging. The inflammatory burden index (IBI) is a novel composite biomarker integrating inflammatory status and immune function. This study aimed to evaluate the diagnostic utility of the IBI in differentiating neonatal pneumonia with and without concomitant sepsis.
methodsWe conducted a retrospective analysis of 1,383 hospitalized neonates, stratified into a pneumonia group (n = 935) and a pneumonia-complicated-by-sepsis group (n = 448). Clinical and laboratory data, including C-reactive protein, neutrophil count, and lymphocyte count, were collected upon admission to calculate the IBI. To assess whether the IBI was independently associated with sepsis, we performed multivariable logistic regression analysis after adjusting for relevant clinical covariates. Finally, Receiver Operating Characteristic (ROC) curve analysis was used to determine the diagnostic performance of the index.
resultsIBI levels were significantly higher in neonates with pneumonia complicated by sepsis compared to those in the pneumonia-only group (P < 0.001). After adjusting for potential confounders in the multivariable model, a higher IBI remained independently associated with an increased prevalence of sepsis. ROC analysis showed that IBI had good diagnostic performance (area under the curve = 0.76, 95% confidence interval: 0.73-0.79, P < 0.001).
conclusionIBI may serve as a non-invasive adjunctive inflammatory marker during the initial clinical assessment of neonates with suspected sepsis.
Indexed as
Identifiers
42919222What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.