ArticleBMC infectious diseases2026
Plasmodium falciparum histidine rich protein 2 plasma concentrations from uncomplicated and severe malaria patients estimated by rapid test band intensity.
Article in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundUnlike peripheral blood parasitaemia, plasma concentrations of PfHRP2 has been established as a measure of total body parasite burden in patients with falciparum malaria, which is prognostic for progression to severe malaria and case fatality. Plasma PfHRP2 concentrations are typically quantified using enzyme-linked immunosorbent assay (ELISA) methods. We assessed whether band intensity on a PfHRP2-based ultrasensitive rapid diagnostic test (RDT) can provide a semi-quantitative measure for plasma PfHRP2 concentrations.
methodsPlasma samples from 60 African patients with severe falciparum malaria and 20 patients with uncomplicated falciparum malaria were assessed for PfHRP2 by ELISA and compared with RDT band intensity, assessed both visually and by digital scanning.
resultsVisual readings of RDT band intensity correlated with PfHRP2 plasma concentrations assessed by ELISA in patients with both uncomplicated (ρ = 0.80) and severe falciparum malaria (ρ = 0.61). Digitally assessed RDT band intensity in patients with severe malaria was higher than in patients with uncomplicated falciparum malaria.
conclusionRDT band intensity correlates with plasma PfHRP2 concentration measured by ELISA and may offer a simple method for estimating total parasite burden in patients with falciparum malaria.
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