Evidence map›Paper›PMID 42919187›Full record

ArticleBMC psychiatry2026

Accelerated brain aging associated with executive deficits in adolescence and early adulthood among individuals with schizophrenia and genetic high risk.

Caijiu Deng, Peiyi Wu, Lingtao Kong, Yifang Zhou, Ziyi Wang, Yuning Zhou, Qikun Sun, Ting Sun, Zhengjiao Tuo, Lei Wang and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in BMC psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Caijiu DengDepartment of Psychiatry, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang, Liaoning, 110004, China.
Peiyi WuDepartment of Psychiatry, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang, Liaoning, 110004, China.
Lingtao KongDepartment of Psychiatry, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang, Liaoning, 110004, China.
Yifang ZhouDepartment of Psychiatry, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang, Liaoning, 110004, China.
Ziyi WangDepartment of Psychiatry, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang, Liaoning, 110004, China.
Yuning ZhouDepartment of Psychiatry, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang, Liaoning, 110004, China.
Qikun SunDepartment of Radiation Oncology, The First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, Liaoning, 110004, China.
Ting SunDepartment of Psychiatry, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang, Liaoning, 110004, China.
Zhengjiao TuoDepartment of Psychiatry, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang, Liaoning, 110004, China.
Lei WangDepartment of Psychiatry, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang, Liaoning, 110004, China.
Yuang LiuDepartment of Psychiatry, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang, Liaoning, 110004, China.
Yuxin ShenDepartment of Psychiatry, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang, Liaoning, 110004, China.
Yanqing TangDepartment of Psychiatry, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang, Liaoning, 110004, China. tangyanqing@cmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAbnormal brain development and cognitive function are present in adolescence and early adulthood of schizophrenia (SZ). However, it is still unclear whether these developmental abnormalities and cognitive deficits occur in adolescence and early adulthood in individuals at genetic high risk (GHR). This study aims to examine brain age gap differences during adolescence and early adulthood in individuals with SZ, GHR, and healthy control (HC), as well as their associations with cognitive function.

methodsThis study recruited a total of 240 subjects aged between 12 and 25, comprising 83 SZ, 48 GHR, and 109 HC. We calculated all participants' brain age gap using their structural MRI. The subtests of Wisconsin Card Sorting Test were utilized to evaluate executive function.

resultsCompared to HC group, both GHR group (P = .021) and SZ (P < .001) group showed greater brain age gap (brain age > chronological age). Notably, within GHR group, greater brain age gap was associated with higher non-perseverative errors in executive function (r=.39, P

conclusionsThis study suggests that changes in brain age during adolescence and early adulthood in SZ and GHR individuals may reflect disease's genetic susceptibility. A greater brain age gap may be associated with the onset and progression of executive deficits in SZ.

Indexed as

AgingBrainExecutive FunctionSchizophreniaAdolescentAdultChildFemaleGenetic Predisposition to DiseaseHumansMagnetic Resonance ImagingMaleNeuropsychological TestsYoung AdultBrain ageExecutive functionGenetic high riskSchizophrenia

Identifiers

PMID42919187

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.