Evidence map›Paper›PMID 42919164›Full record

ArticleBMC cardiovascular disorders2026

Heart-reactive antibody levels differentially associate with ventricular function in hereditary cardiomyopathies.

Dennis Schiffer, Boshra Afshar, Daria Grosser, Juliana Pet, Lena Schmidbauer, Maximilian Bauser, Gustavo Ramos, Valerie Boivin-Jahns, Roland Jahns, Stefan Frantz and 5 more

Abstract read
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In one paragraph

Article in BMC cardiovascular disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Dennis SchifferDepartment of Clinical Research & Epidemiology, Comprehensive Heart Failure Center (CHFC), University Hospital Würzburg, Würzburg, Germany.
Boshra AfsharInstitute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany.
Daria GrosserInstitute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany.
Juliana PetInstitute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany.
Lena SchmidbauerInstitute for Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany.
Maximilian BauserDepartment of Clinical Research & Epidemiology, Comprehensive Heart Failure Center (CHFC), University Hospital Würzburg, Würzburg, Germany.
Gustavo RamosDepartment of Clinical Research & Epidemiology, Comprehensive Heart Failure Center (CHFC), University Hospital Würzburg, Würzburg, Germany.
Valerie Boivin-JahnsInstitute for Pharmacology and Toxicology, University of Würzburg, Würzburg, Germany.
Roland JahnsInterdisciplinary Bank of Data and Biomaterials (ibdw), University Hospital Würzburg, Würzburg, Germany.
Stefan FrantzDepartment of Clinical Research & Epidemiology, Comprehensive Heart Failure Center (CHFC), University Hospital Würzburg, Würzburg, Germany.
Peter HeuschmannInstitute for Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany.
Stefan StörkDepartment of Clinical Research & Epidemiology, Comprehensive Heart Failure Center (CHFC), University Hospital Würzburg, Würzburg, Germany.
Brenda Gerull *Department of Medicine I, University Hospital Würzburg, Würzburg, Germany.
Niklas Beyersdorf *Institute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany. niklas.beyersdorf@vim.uni-wuerzburg.de.
Caroline Morbach *Department of Clinical Research & Epidemiology, Comprehensive Heart Failure Center (CHFC), University Hospital Würzburg, Würzburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundgCMP are a major cause of cardiovascular morbidity and mortality. While agonistic anti-β1-adrenergic receptor antibodies (anti-β1AR-EC

methodsOne hundred gCMP patients with confirmed genetic variants in cardiomyopathy genes were compared with 100 age- and sex-matched healthy individuals. Antibody reactivities were quantified using bead-based flow cytometric assays against cardiac antigens: The second extracellular loop of the β1 adrenergic receptor (β1AR-EC

resultsgCMP patients showed higher anti-TPI3 and lower anti-TPM1 antibody levels compared to controls indicating increased induction of the former and loss of the latter in gCMP patients. Age and sex influenced HRA patterns in both groups. Anti-MYH6 and anti-TPM1 antibody levels were negatively associated with left ventricular ejection fraction (LVEF), both overall and within specific gCMP subtypes, including hypertrophic and arrhythmogenic cardiomyopathy. Additionally, anti-MYH6 antibody levels were negatively associated with right ventricular function, measured by tricuspid annular plane systolic excursion (TAPSE).

conclusionOur findings stress the diagnostic potential of HRA profiling and indicate that gCMP patients might profit from therapeutic targeting of HRA.

Indexed as

AutoantibodiesCardiomyopathiesStroke VolumeVentricular Function, LeftAdultBiomarkersCardiac MyosinsCase-Control StudiesFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedMyosin Heavy ChainsPhenotypeReceptors, Adrenergic, beta-1AutoantibodiesBiomarkersCardiac MyosinsMyosin Heavy ChainsReceptors, Adrenergic, beta-1TPM1 protein, humanTropomyosinAutoimmunityGenetic cardiomyopathyHeart-reactive antibodiesMyosin heavy chainTropomyosin

Identifiers

PMID42919164

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.