ArticleBMC cardiovascular disorders2026
Associations of a nutrition-inflammation index and vascular aging with mortality in adults with diabetes or prediabetes and cardiovascular disease.
Article in BMC cardiovascular disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdults with prediabetes or diabetes and cardiovascular disease (CVD) face a substantial burden of premature mortality. Chronic inflammation, malnutrition and vascular aging are key pathways linking dysglycaemia and CVD to adverse outcomes. The Advanced Lung Cancer Inflammation Index (ALI) reflects systemic inflammation and nutritional status, while estimated pulse wave velocity (ePWV) serves as a surrogate of vascular aging. However, their independent and joint associations with mortality in dysglycemic adults with CVD remain unclear.
methodsNHANES 1999-2018 data comprising 101,316 participants were analyzed. After exclusions, adults ≥ 20 years with prediabetes/diabetes and CVD were included (n = 1,992). ALI and ePWV were analysed as continuous variables and cross-classified using maximally selected cut-points. Survey-weighted Cox models, restricted cubic splines and subgroup/sensitivity analyses were applied. Time-dependent receiver operating characteristic curves and C-indices were used to compare prognostic discrimination.
resultsHigher ALI was inversely associated with all-cause, cardiovascular, and premature mortality, whereas higher ePWV was positively associated with all-cause and cardiovascular mortality. Per 10-unit increment in ALI, fully adjusted hazard ratios (HRs) were 0.899 (95% CI 0.872-0.928) for all-cause mortality, 0.938 (0.885-0.995) for cardiovascular mortality, and 0.889 (0.837-0.945) for premature mortality. For ePWV, the corresponding HRs per 1 m/s increment were 1.139 (1.072-1.211) for all-cause mortality and 1.216 (1.102-1.341) for cardiovascular mortality. In joint analyses, combined ALI-ePWV categories showed a risk gradient: participants with high ALI/low ePWV had the lowest risks of all-cause mortality (HR 0.382, 95% CI 0.280-0.520), cardiovascular mortality (HR 0.379, 95% CI 0.228-0.630), and premature mortality (HR 0.402, 95% CI 0.245-0.659) compared with those with low ALI/high ePWV.
conclusionsALI and ePWV provide complementary information on systemic inflammation-nutrition status and vascular ageing, and their combined categories define distinct risk strata for mortality in adults with dysglycaemia and CVD. Their combined categories may help characterize mortality-risk heterogeneity and inform future risk-assessment studies in this high-risk population.
Indexed as
Identifiers
42919143What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.