ArticleOphthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)2026
Early Axial Length Response Predicts Long-Term Myopia Control in Children Undergoing Orthokeratology.
Article in Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo evaluate whether early axial length (AL) change after 6 months of orthokeratology (OK) wear serves as a clinically meaningful biomarker for predicting long-term myopia control after 2 years.
methodsThis retrospective analysis included 101 children from a multicentre OK cohort who completed 24 months of follow‑up, with AL measured at baseline and at 6, 12, 18 and 24 months. Early AL shortening was defined as a ≥0.01 mm reduction after 6 months. Longitudinal AL change was assessed using linear mixed‑effects models. To evaluate predictive utility, separate logistic regression models were fitted using the 6-month AL change (ΔAL₆
resultsFourteen children (13.9%) showed early AL shortening. Mixed‑effects modelling showed a significant time × shortening interaction (p < 0.001), with shorteners elongating by ∼0.006 mm/month versus ∼0.019 mm/month in non‑shorteners, yielding ∼0.33 mm less AL growth at 24 months. ΔAL₆
conclusionsEarly AL change after 6 months of OK wear is a useful biomarker for risk‑stratifying long‑term myopia control response. Children with ΔAL₆
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