ReviewClinical reviews in allergy & immunology2026
Autoimmunity and Inflammaging in Male Infertility.
Review in Clinical reviews in allergy & immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
Funding
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Abstract
Male factors contribute, alone or in combination with female-related ones, to approximately 40-50% of infertility in couples. Within the spectrum of male infertility, growing evidence indicates that autoimmune mechanisms and chronic inflammation can impair spermatogenesis, sperm function, and reproductive outcomes. The disruption of the testicular immune privilege, blood-testis barrier dysfunction, local inflammatory pathways, and antisperm antibodies represent the best-characterized immune-mediated mechanisms, although their clinical relevance varies and several mechanistic observations remain derived from preclinical models. Systemic autoimmune and chronic inflammatory diseases may also affect male reproductive function through inflammatory cytokines, endocrine dysregulation of the hypothalamic-pituitary-gonadal axis, sexual dysfunction, and treatment-related gonadotoxicity. Emerging data also implicate the gut-testis axis and age-associated low-grade inflammation (inflammaging) as potential contributors to testicular immune remodeling, oxidative stress, and declining reproductive function. This narrative review is intended to encompass disease-specific available reviews and synthesize original research, clinical studies, and systematic reviews published mainly between 2010 and 2026. We distinguish established clinical evidence from experimental or hypothesis-generating data and discuss implications for fertility preservation, assisted reproduction, and individualized management. Integrating reproductive immunology with the clinical evaluation of male infertility may improve risk stratification while avoiding overinterpretation of still-limited immune biomarkers and therapeutic evidence.
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Identifiers
42919000What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.