ArticleMethods in molecular biology (Clifton, N.J.)2027
The Humanized Mouse Model of AGS: A Preclinical System for Analyzing Hypersensitivity to α-Gal and Potential Allergenic Epitopes.
Article in Methods in molecular biology (Clifton, N.J.), 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Humanized mouse models are indispensable in vivo experimental platforms for investigating human-specific biological processes in a controlled and reproducible environment, serving as a preclinical link between basic research and application in translational research. Alpha-Gal syndrome (AGS) is one of the emerging pathologies that highlight the need for a murine system capable of mimicking the reproduction of key aspects of human immune and allergic responses. Humanized α1,3GalT-knockout (KO) mice have expanded research on immunological basis of the syndrome and advanced in preclinical research. Here we present a detailed experimental protocol of KO validation and studying α1,3GalT-KO in vivo immune responses to α-Gal and/or other epitopes or potential allergens.
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