ReviewInternational journal of implant dentistry2026
Osteoblast responses to implant materials and the role of vitamin D in dental implant osseointegration: a narrative review.
Review in International journal of implant dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
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Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis narrative review aims to summarise current evidence on osteoblast responses to commonly used dental implant materials and to evaluate the potential role of vitamin D in modulating biological processes involved in dental implant osseointegration.
methodsA narrative literature review was performed using PubMed/MEDLINE, Google Scholar, and reference lists of relevant articles and reviews. The literature was last updated in September 2026. The review focused on implant materials and surface characteristics, osteoblast adhesion, proliferation, differentiation, mineralised matrix formation, vitamin D biology, and clinical evidence related to vitamin D and dental implant osseointegration.
resultsCurrent evidence indicates that implant surface characteristics, including roughness, topography, surface chemistry, hydrophilicity, and coatings, influence osteoblast behaviour and the biological response at the bone-implant interface. Titanium remains the most established implant material, while zirconia and titanium-zirconium alloys have shown favourable biological and clinical performance in selected indications. Vitamin D is known to be biologically relevant for bone metabolism and osteoblast activity, and experimental studies suggest that it may support osteogenic differentiation and mineralised matrix formation. However, current human clinical evidence regarding vitamin D and implant outcomes remains limited and heterogeneous.
conclusionsOsseointegration is influenced by a complex interaction between implant material characteristics, surface properties, osteoblast responses, systemic vitamin D status, and host-related biological factors. Although vitamin D is known to be biologically relevant and experimental findings are promising, there is currently insufficient evidence to show that vitamin D has variable effects on osseointegration around titanium, zirconia, or titanium-zirconium implants. Further in vitro, in vivo, and clinical studies are needed using clearly defined implant materials, surface characteristics, vitamin D status or supplementation protocols, and clinical outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.