ArticleAAPS PharmSciTech2026
Hot-Stage Microscopy as a Quantitative Preformulation Tool for Assessing API Particle Dissolution in Molten Polymer Matrices.
Article in AAPS PharmSciTech, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-melting-point active pharmaceutical ingredients (APIs) frequently undergo amorphization during hot-melt extrusion (HME) through progressive dissolution and incorporation in a softened polymer rather than by direct melting. The kinetics of this process are strongly influenced by particle size, yet rapid experimental methods for evaluating particle dissolution behaviour in the softened polymer prior to extrusion remain limited. In this work, a quantitative hot-stage microscopy (HSM)-based workflow combined with image analysis was developed to evaluate particle-size-dependent dissolution of a model high-melting-point API into softened Kollidon
Indexed as
Identifiers
42918941What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.