Evidence map›Paper›PMID 42918939›Full record

ArticleAAPS PharmSciTech2026

Understanding the High Pharmacokinetic Variability of 5-Aminosalicylic Acid Drug Products Using Compartmental, Semi-mechanistic, and Mechanistic Pharmacokinetic Models.

Sakshi Kunjir, Sadhana Dhyagala, Ayush Rohila, Ankit Kumar, Prakash Kumar Sirvi, Rajkumar Malayandi

Abstract read
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In one paragraph

Article in AAPS PharmSciTech, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sakshi KunjirDepartment of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hajipur, Export Promotion Industrial Park (EPIP), Zandaha Road, NH322, Hajipur, Bihar, 844102, India.ORCID http://orcid.org/0009-0008-1062-5860
Sadhana DhyagalaDepartment of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hajipur, Export Promotion Industrial Park (EPIP), Zandaha Road, NH322, Hajipur, Bihar, 844102, India.ORCID http://orcid.org/0000-0003-1834-7750
Ayush RohilaDepartment of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hajipur, Export Promotion Industrial Park (EPIP), Zandaha Road, NH322, Hajipur, Bihar, 844102, India.ORCID http://orcid.org/0009-0003-9362-8365
Ankit KumarDepartment of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hajipur, Export Promotion Industrial Park (EPIP), Zandaha Road, NH322, Hajipur, Bihar, 844102, India.ORCID http://orcid.org/0009-0002-0603-1492
Prakash Kumar SirviDepartment of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hajipur, Export Promotion Industrial Park (EPIP), Zandaha Road, NH322, Hajipur, Bihar, 844102, India.ORCID http://orcid.org/0009-0003-4148-171X
Rajkumar MalayandiDepartment of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hajipur, Export Promotion Industrial Park (EPIP), Zandaha Road, NH322, Hajipur, Bihar, 844102, India. rajkumar.ceutics@niperhajipur.ac.in.ORCID http://orcid.org/0000-0003-1435-6115

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

5-Aminosalicylic acid (5-ASA) is a cornerstone therapy for ulcerative colitis (UC), but its clinical performance is highly variable due to pH-dependent solubility, formulation design, and intestinal metabolism. Significant intersubject variability (ISV), particularly for modified-release drug products such as Lialda (> 75% variability in C

Indexed as

MesalamineModels, BiologicalAdministration, OralAnti-Inflammatory Agents, Non-SteroidalArea Under CurveChemistry, PharmaceuticalColitis, UlcerativeDrug LiberationHumansHydrogen-Ion ConcentrationSolubilityAnti-Inflammatory Agents, Non-SteroidalMesalamine5-Aminosalicylic acidpentasapharmacokinetic variabilityphysiologically based pharmacokinetic model

Identifiers

PMID42918939

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.