ReviewNature reviews. Rheumatology2026
Primary cilia as regulators of fibrosis and potential therapeutic targets.
Review in Nature reviews. Rheumatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fibrosis complicates numerous rheumatic diseases and accounts for considerable morbidity and mortality. Developing more effective treatments will require a deeper understanding of fibrosis. Discoveries over the past decade implicate the ubiquitous cellular organelle primary cilium in modulating tissue repair in health and disease. In particular, emerging evidence shows that dysregulated function of primary cilia might have a previously unrecognized pathogenic role in fibrosis across multiple organs and conditions. Historically considered vestigial organelles, primary cilia are complex microtubule-based solitary organelles present on most vertebrate cells. They function as signalling hubs for Toll-like receptors and receptors for morphogen and growth factors and thereby regulate physiological and pathological tissue remodelling. Pharmacological modulation of primary cilia represents a potential approach to target cellular function and could offer a future therapeutic strategy for fibrotic diseases.
Identifiers
42918857What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.