ArticleCommunications biology2026
In vivo replication of a fully functional nerve net in a clonally reproducing animal.
Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
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Abstract
Nerve nets are considered the evolutionarily oldest form of nervous system. How such networks develop and how complex nervous systems become fully functional is largely unknown. In a phylogenetically ancient animal, the freshwater polyp Hydra, we demonstrate how a nerve net consisting of distinct neuronal populations is precisely replicated over the course of asexual proliferation by budding. During this process, precursor cells first accumulate at the site of the emerging neural network, followed by a stepwise formation of functional neural circuits composed of distinct neuronal populations. These circuits become arranged according to an accurately controlled spatiotemporal pattern and take control of behaviors independently of the existing parental network. Since similar processes also govern the formation of more complex nervous systems in other invertebrates and vertebrates, we suggest that the basic requirements for a neuronal network to replicate were already in place at the beginning of the evolution of the nervous system.
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Registered trials
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